論文 - 詳細
| RRC ID | 60056 |
|---|---|
| 著者 | Huang CC, Chiou CH, Liu SC, Hu SL, Su CM, Tsai CH, Tang CH. |
| タイトル | Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis. |
| ジャーナル | J Pineal Res |
| Abstract |
The hormone melatonin has many properties, including antioxidant, anti-inflammatory, and immunomodulatory effects. Melatonin has been demonstrated to be beneficial in several inflammatory autoimmune diseases, but its effects in rheumatoid arthritis (RA) remain controversial. We sought to determine how melatonin regulates inflammation in RA. We found that melatonin dose-dependently inhibits tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β expression through the PI3K/AKT, ERK, and NF-κB signaling pathways. We also identified that melatonin inhibits TNF-α and IL-1β production by upregulating miR-3150a-3p expression. Synovial tissue specimens from RA patients and culture of human rheumatoid fibroblast-like synoviocytes confirmed that the MT1 receptor is needed for the anti-inflammatory activities of melatonin. Importantly, melatonin also significantly reduced paw swelling, cartilage degradation, and bone erosion in the collagen-induced arthritis mouse model. Our results indicate that melatonin ameliorates RA by inhibiting TNF-α and IL-1β production through downregulation of the PI3K/AKT, ERK, NF-κB signaling pathways, as well as miR-3150a-3p overexpression. The role of melatonin as an adjuvant treatment in patients with RA deserves further clinical studies. |
| 巻・号 | 66(3) |
| ページ | e12560 |
| 公開日 | 2019-4-1 |
| DOI | 10.1111/jpi.12560 |
| PMID | 30648758 |
| MeSH | Animals Arthritis, Experimental / metabolism Arthritis, Experimental / pathology Arthritis, Rheumatoid / metabolism* Arthritis, Rheumatoid / pathology Cartilage, Articular / drug effects Cartilage, Articular / pathology Fibroblasts / drug effects* Fibroblasts / metabolism Gene Expression Regulation / drug effects Humans Interleukin-1beta / biosynthesis* Melatonin / pharmacology* Mice MicroRNAs / metabolism Signal Transduction / drug effects Synovial Membrane / drug effects Synovial Membrane / metabolism Tumor Necrosis Factor-alpha / biosynthesis* |
| IF | 14.528 |
| 引用数 | 21 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MH7A(RCB1512) |