RRC ID 60067
Author Frank T, Mönig NR, Satou C, Higashijima SI, Friedrich RW.
Title Associative conditioning remaps odor representations and modifies inhibition in a higher olfactory brain area.
Journal Nat Neurosci
Abstract Intelligent behavior involves associations between high-dimensional sensory representations and behaviorally relevant qualities such as valence. Learning of associations involves plasticity of excitatory connectivity, but it remains poorly understood how information flow is reorganized in networks and how inhibition contributes to this process. We trained adult zebrafish in an appetitive odor discrimination task and analyzed odor representations in a specific compartment of the posterior zone of the dorsal telencephalon (Dp), the homolog of mammalian olfactory cortex. Associative conditioning enhanced responses with a preference for the positively conditioned odor. Moreover, conditioning systematically remapped odor representations along an axis in coding space that represented attractiveness (valence). Interindividual variations in this mapping predicted variations in behavioral odor preference. Photoinhibition of interneurons resulted in specific modifications of odor representations that mirrored effects of conditioning and reduced experience-dependent, interindividual variations in odor-valence mapping. These results reveal an individualized odor-to-valence map that is shaped by inhibition and reorganized during learning.
Volume 22(11)
Pages 1844-1856
Published 2019-11
DOI 10.1038/s41593-019-0495-z
PII 10.1038/s41593-019-0495-z
PMID 31591559
PMC PMC6858881
MeSH Animals Animals, Genetically Modified Association Learning / physiology* Brain Mapping* Discrimination Learning / physiology Female Individuality Male Neural Inhibition / physiology* Odorants Olfactory Cortex / physiology* Olfactory Perception / physiology* Zebrafish
IF 21.126
Times Cited 3
Resource
Zebrafish Tg(gad1b:Gal4)