RRC ID 60076
Author Wanner AA, Friedrich RW.
Title Whitening of odor representations by the wiring diagram of the olfactory bulb.
Journal Nat Neurosci
Abstract Neuronal computations underlying higher brain functions depend on synaptic interactions among specific neurons. A mechanistic understanding of such computations requires wiring diagrams of neuronal networks. In this study, we examined how the olfactory bulb (OB) performs 'whitening', a fundamental computation that decorrelates activity patterns and supports their classification by memory networks. We measured odor-evoked activity in the OB of a zebrafish larva and subsequently reconstructed the complete wiring diagram by volumetric electron microscopy. The resulting functional connectome revealed an over-representation of multisynaptic connectivity motifs that mediate reciprocal inhibition between neurons with similar tuning. This connectivity suppressed redundant responses and was necessary and sufficient to reproduce whitening in simulations. Whitening of odor representations is therefore mediated by higher-order structure in the wiring diagram that is adapted to natural input patterns.
Volume 23(3)
Pages 433-442
Published 2020-3
DOI 10.1038/s41593-019-0576-z
PII 10.1038/s41593-019-0576-z
PMID 31959937
PMC PMC7101160
MeSH Algorithms Animals Connectome Electrophysiological Phenomena / physiology Larva Memory / physiology Models, Neurological Nerve Net / anatomy & histology Nerve Net / physiology Odorants* Olfactory Bulb / physiology* Olfactory Pathways / physiology Olfactory Perception Synapses / physiology Zebrafish
IF 21.126
Times Cited 0
Resource
Zebrafish Tg(vglut2a:lRl-GFP)