RRC ID 60095
Author Leung LC, Wang GX, Madelaine R, Skariah G, Kawakami K, Deisseroth K, Urban AE, Mourrain P.
Title Neural signatures of sleep in zebrafish.
Journal Nature
Abstract Slow-wave sleep and rapid eye movement (or paradoxical) sleep have been found in mammals, birds and lizards, but it is unclear whether these neuronal signatures are found in non-amniotic vertebrates. Here we develop non-invasive fluorescence-based polysomnography for zebrafish, and show-using unbiased, brain-wide activity recording coupled with assessment of eye movement, muscle dynamics and heart rate-that there are at least two major sleep signatures in zebrafish. These signatures, which we term slow bursting sleep and propagating wave sleep, share commonalities with those of slow-wave sleep and paradoxical or rapid eye movement sleep, respectively. Further, we find that melanin-concentrating hormone signalling (which is involved in mammalian sleep) also regulates propagating wave sleep signatures and the overall amount of sleep in zebrafish, probably via activation of ependymal cells. These observations suggest that common neural signatures of sleep may have emerged in the vertebrate brain over 450 million years ago.
Volume 571(7764)
Pages 198-204
Published 2019-7
DOI 10.1038/s41586-019-1336-7
PII 10.1038/s41586-019-1336-7
PMID 31292557
PMC PMC7081717
MeSH Animals Biological Evolution Brain / cytology Brain / drug effects Brain / physiology Brain / physiopathology Ependyma / cytology Eye Movements Fluorescence Heart Rate Hypnotics and Sedatives / pharmacology Hypothalamic Hormones / metabolism Melanins / metabolism Neurons / drug effects Neurons / physiology* Pigmentation / physiology Pituitary Hormones / metabolism Polysomnography / methods Sleep / drug effects Sleep / physiology* Sleep Deprivation / physiopathology Sleep, REM / drug effects Sleep, REM / physiology Sleep, Slow-Wave / drug effects Sleep, Slow-Wave / physiology Zebrafish / physiology*
IF 43.07
Times Cited 15