論文 - 詳細
| RRC ID | 60138 |
|---|---|
| 著者 | Egashira N, Goto Y, Takahashi R, Iba H, Yamamoto S, Watanabe T, Kubota K, Kawashiri T, Taniguchi C, Katsurabayashi S, Iwasaki K. |
| タイトル | Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats. |
| ジャーナル | J Pharmacol Sci |
| Abstract |
Oxaliplatin is a key drug used in the management of solid tumors, such as colorectal cancer; however, it causes peripheral neuropathy. In this study, we investigated the effect of ibudilast, a phosphodiesterase inhibitor, on oxaliplatin-induced mechanical allodynia and histological changes in rats. Ibudilast (7.5 mg/kg, i.p., 5 times per week) reduced mechanical allodynia and histological changes induced by oxaliplatin (4 mg/kg, i.p., twice a week). In contrast, ibudilast (0.01-10 μM) had no effect on oxaliplatin-induced tumor cytotoxicity in murine colon adenocarcinoma 26 cells. These findings suggest that ibudilast could be useful for preventing oxaliplatin-induced peripheral neuropathy in clinical settings. |
| 巻・号 | 147(1) |
| ページ | 114-117 |
| 公開日 | 2021-9-1 |
| DOI | 10.1016/j.jphs.2021.06.004 |
| PII | S1347-8613(21)00060-8 |
| PMID | 34294361 |
| MeSH | Adenocarcinoma / drug therapy Adenocarcinoma / pathology Animals Colonic Neoplasms / drug therapy Colonic Neoplasms / pathology Hyperalgesia / chemically induced* Hyperalgesia / pathology Hyperalgesia / prevention & control* Indolizines Male Mice Oxaliplatin / adverse effects* Oxaliplatin / therapeutic use Peripheral Nervous System Diseases / chemically induced* Peripheral Nervous System Diseases / pathology Peripheral Nervous System Diseases / prevention & control* Phosphodiesterase Inhibitors / pharmacology* Phosphodiesterase Inhibitors / therapeutic use* Pyrazoles Pyridines / pharmacology* Pyridines / therapeutic use* Rats Rats, Sprague-Dawley Tumor Cells, Cultured |
| リソース情報 | |
| ヒト・動物細胞 | Colon-26(RCB2657) |