論文 - 詳細
| RRC ID | 60140 |
|---|---|
| 著者 | Pang S, Li X, Wu D, Li H, Wang X. |
| タイトル | Tuning inflammation response via adjusting microstructure of hydroxyapatite and biomolecules modification. |
| ジャーナル | Colloids Surf B Biointerfaces |
| Abstract |
Excellent biocompatibility and inflammatory regulation ability are essential to bone repair materials. Herein, Rod-like HAP with a diameter of 0.1 μm and Flake-like HAP with a width of 0.5-1 μm were synthesized by hydrothermal method, and then combined with two kinds of biomolecules, Icariin and Kaempferol. Two kinds of HAPs have similar crystal structure, but different zeta potentials and specific surface area. Rod-like HAP possesses stronger loading capacity and internalization efficiency than Flake-like one. in vitro inflammation assay reveals that HAP particles up-regulate the expression of IL-1β, TNF-α, IL-6, IL-10, IFN-γ and IL-2 cytokines. HAP particles loaded with Icariin or Kaempferol biomolecules up-regulate anti-inflammatory cytokines and down-regulate the expression of inflammatory cytokines. |
| 巻・号 | 177 |
| ページ | 496-505 |
| 公開日 | 2019-5-1 |
| DOI | 10.1016/j.colsurfb.2019.02.026 |
| PII | S0927-7765(19)30108-0 |
| PMID | 30807964 |
| MeSH | Caspases / chemistry Caspases / metabolism Cell Survival / drug effects Cells, Cultured Fluorescein / chemistry* Fluorescein / metabolism Humans Hydroxyapatites / chemistry* Hydroxyapatites / pharmacology Inflammation / metabolism* Molecular Structure Ovalbumin / chemistry* Ovalbumin / metabolism Particle Size Surface Properties THP-1 Cells p38 Mitogen-Activated Protein Kinases / chemistry p38 Mitogen-Activated Protein Kinases / metabolism |
| IF | 3.973 |
| 引用数 | 1 |
| リソース情報 | |
| ヒト・動物細胞 | THP-1 |