論文 - 詳細
| RRC ID | 60142 |
|---|---|
| 著者 | Giriwono PE, Shirakawa H, Ohsaki Y, Sato S, Aoyama Y, Ho HJ, Goto T, Komai M. |
| タイトル | Geranylgeraniol Suppresses the Expression of IRAK1 and TRAF6 to Inhibit NFκB Activation in Lipopolysaccharide-Induced Inflammatory Responses in Human Macrophage-Like Cells. |
| ジャーナル | Int J Mol Sci |
| Abstract |
Geranylgeraniol (GGOH), a natural isoprenoid found in plants, has anti-inflammatory effects via inhibiting the activation of nuclear factor-kappa B (NFκB). However, its detailed mechanism has not yet been elucidated. Recent studies have revealed that isoprenoids can modulate signaling molecules in innate immune responses. We found that GGOH decreased the expression of lipopolysaccharide (LPS)-induced inflammatory genes in human macrophage-like THP-1 cells. Furthermore, we observed that the suppression of NFκB signaling proteins, in particular interleukin-1 receptor-associated kinase 1 (IRAK1) and tumor necrosis factor receptor-associated factor 6 (TRAF6), occurred in GGOH-treated cells prior to LPS stimulation, suggesting an immunomodulatory effect. These results indicate that GGOH may modulate and help prevent excessive NFκB activation that can lead to numerous diseases. |
| 巻・号 | 20(9) |
| 公開日 | 2019-5-10 |
| DOI | 10.3390/ijms20092320 |
| PII | ijms20092320 |
| PMID | 31083375 |
| PMC | PMC6540148 |
| MeSH | Animals Cell Line Diterpenes / pharmacology* Humans Inflammation / genetics Inflammation / pathology* Interleukin-1 Receptor-Associated Kinases / metabolism* Lipopolysaccharides Macrophages / drug effects Macrophages / metabolism* Macrophages / pathology* Mice Models, Biological NF-kappa B / metabolism* Phosphorylation / drug effects RAW 264.7 Cells RNA, Messenger / genetics RNA, Messenger / metabolism Signal Transduction / drug effects THP-1 Cells TNF Receptor-Associated Factor 6 / metabolism* |
| IF | 4.183 |
| 引用数 | 1 |
| リソース情報 | |
| ヒト・動物細胞 | THP-1(RCB1189) |