論文 - 詳細
| RRC ID | 60274 |
|---|---|
| 著者 | Higuchi T, Suzuki N, Nakaya S, Omagari S, Yoneda M, Hanioka T, Hirofuji T. |
| タイトル | Effects of Lactobacillus salivarius WB21 combined with green tea catechins on dental caries, periodontitis, and oral malodor. |
| ジャーナル | Arch Oral Biol |
| Abstract |
OBJECTIVE:To evaluate the combined use of Lactobacillus salivarius WB21 and (-)-epigallocatechin gallate (EGCg) for oral health maintenance. DESIGN:The effects of L. salivarius WB21 on growth of Streptococcus mutans, the insoluble glucan produced by S. mutans, and on growth of Porphyromonas gingivalis were evaluated in vitro. In addition, the susceptibility of five oral pathogenic bacteria and L. salivarius WB21 to EGCg, the inhibiting effect of EGCg on methyl mercaptan, and the effects of L. salivarius WB21 and EGCg in combination on growth of P. gingivalis were examined. RESULTS:Lactobacillus salivarius WB21 showed concentration-dependent inhibition of the growth of S. mutans. Addition of L. salivarius WB21 inhibited production of the insoluble glucan by S. mutans (p < 0.001). A filtrate of L. salivarius WB21 culture solution inhibited growth of P. gingivalis (p < 0.001 vs. control), and this effect was enhanced when it was used in combination with EGCg (p < 0.001 vs. the addition of L. salivarius WB21). In addition, EGCg directly inhibited methyl mercaptan in a concentration-dependent manner (p < 0.001). Concerning bacterial susceptibility to EGCg, growth of P. gingivalis, Prevotella intermedia, and Fusobacterium nucleatum was inhibited at 2.5 mg/mL of EGCg, while that of L. salivarius WB21 was inhibited at 25 mg/mL EGCg. CONCLUSIONS:Our results imply that L. salivarius WB21 may be useful for controlling dental caries, periodontitis, and oral malodor. In addition, the effects of L. salivarius WB21 on periodontitis and oral malodor may be synergistically enhanced by use in combination with EGCg. |
| 巻・号 | 98 |
| ページ | 243-247 |
| 公開日 | 2019-2-1 |
| DOI | 10.1016/j.archoralbio.2018.11.027 |
| PII | S0003-9969(18)30424-2 |
| PMID | 30530235 |
| MeSH | Antibiosis Catechin / analogs & derivatives Catechin / pharmacology* Catechin / physiology Dental Caries / microbiology* Dental Caries / prevention & control Fusobacterium nucleatum / drug effects Fusobacterium nucleatum / growth & development Glucans / metabolism Halitosis / microbiology* Halitosis / prevention & control Ligilactobacillus salivarius / drug effects Ligilactobacillus salivarius / physiology* Microbial Sensitivity Tests Periodontitis / microbiology* Periodontitis / prevention & control Porphyromonas gingivalis / drug effects Porphyromonas gingivalis / growth & development Prevotella intermedia / drug effects Prevotella intermedia / growth & development Probiotics Streptococcus mutans / drug effects Streptococcus mutans / growth & development Streptococcus mutans / metabolism Tea / chemistry* |
| IF | 1.663 |
| 引用数 | 4 |
| リソース情報 | |
| 一般微生物 | JCM5705 JCM5175 JCM8525 JCM8532 JCM8577 |