Reference - Detail
| RRC ID | 60287 |
|---|---|
| Author | Takusagawa S, Satoh Y, Ohtsu I, Dairi T. |
| Title | Ergothioneine production with Aspergillus oryzae. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
To establish a reliable and practical ergothioneine (ERG) supply, we employed fermentative ERG production using Aspergillus oryzae, a fungus used for food production. We heterologously overexpressed the egt-1 and -2 genes of Neurospora crassa in A. oryzae and succeeded in producing ERG (231.0 mg/kg of media, which was 20 times higher than the wild type). Abbreviations: ERG: ergothioneine; HER: hercynine; Cys-HER: hercynylcysteine-sulfoxide; SAM: S-adenosylmethionine; SAH: S-adenosylhomocysteine; l-His: l-histidine; l-Cys: l-cysteine; LC-ESI-MS: liquid chromatography-electrospray ionization-mass spectrometry. |
| Volume | 83(1) |
| Pages | 181-184 |
| Published | 2019-1-1 |
| DOI | 10.1080/09168451.2018.1527210 |
| PMID | 30286703 |
| MeSH | Antioxidants / metabolism Aspergillus oryzae / metabolism* Chromatography, Liquid Ergothioneine / biosynthesis* Ergothioneine / genetics Fermentation Genes, Fungal Neurospora crassa / genetics Spectrometry, Mass, Electrospray Ionization |
| IF | 1.297 |
| Times Cited | 4 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 9 |
| Altmetric score changes over past 6months | 3.0 |
| Resource | |
| General Microbes | JCM19069 |