| RRC ID |
60355
|
| 著者 |
Kokubo T, Komano Y, Tsuji R, Fujiwara D, Fujii T, Kanauchi O.
|
| タイトル |
The Effects of Plasmacytoid Dendritic Cell-Stimulative Lactic Acid Bacteria, Lactococcus lactis Strain Plasma, on Exercise-Induced Fatigue and Recovery via Immunomodulatory Action.
|
| ジャーナル |
Int J Sport Nutr Exerc Metab
|
| Abstract |
The unique lactic acid bacteria, Lactococcus lactis strain plasma (LC-Plasma), stimulates plasmacytoid dendritic cells, which play an important role in viral infection. The authors previously reported that LC-Plasma reduced the number of days athletes experienced cold-like symptoms and fatigue feelings after high-intensity exercise training; however, the mechanism was unclear. In this study, the authors investigated the effect of LC-Plasma on recovery from physical damage after single exercise on a treadmill in BALB/c mice model. Oral administration of LC-Plasma (AIN-93G + 0.029% LC-Plasma) for 4 weeks significantly improved the locomotor reduction after treadmill exercise. This effect was not detected in mice receiving Lactobacillus rhamnosus GG, representative probiotics strain. LC-Plasma also improved voluntary locomotor activity after exercise. Blood and muscle sample analysis indicated that LC-Plasma affects plasmacytoid dendritic cell activation, which, in turn, attenuates muscle degenerative genes and the concentration of fatigue-controlled cytokine transforming growth factor-β.
|
| 巻・号 |
29(4)
|
| ページ |
354–358
|
| 公開日 |
2019-7-1
|
| DOI |
10.1123/ijsnem.2018-0377
|
| PMID |
31034253
|
| MeSH |
Administration, Oral
Animals
Dendritic Cells / cytology*
Dendritic Cells / microbiology
Fatigue*
Lactobacillales / physiology
Lactococcus lactis / physiology*
Mice, Inbred BALB C
Motor Activity
Muscle, Skeletal / physiology*
Physical Conditioning, Animal / physiology*
Probiotics
Transforming Growth Factor beta1 / blood
|
| IF |
3.884
|
| 引用数 |
1
|
| リソース情報 |
| 一般微生物 |
JCM5805 |
