論文 - 詳細
| RRC ID | 60580 |
|---|---|
| 著者 | Wang RJ, Zhang SY, Ye YH, Yu Z, Qi H, Zhang H, Xue ZL, Wang JD, Wu M. |
| タイトル | Three New Isoflavonoid Glycosides from the Mangrove-Derived Actinomycete Micromonospora aurantiaca 110B. |
| ジャーナル | Mar Drugs |
| Abstract |
The mangrove ecosystem is a rich resource for the discovery of actinomycetes with potential applications in pharmaceutical science. Besides the genus Streptomyces, Micromonospora is also a source of new bioactive agents. We screened Micromonospora from the rhizosphere soil of mangrove plants in Fujian province, China, and 51 strains were obtained. Among them, the extracts of 12 isolates inhibited the growth of human lung carcinoma A549 cells. Strain 110B exhibited better cytotoxic activity, and its bioactive constituents were investigated. Consequently, three new isoflavonoid glycosides, daidzein-4'-(2-deoxy-α-l-fucopyranoside) (1), daidzein-7-(2-deoxy-α-l-fucopyranoside) (2), and daidzein-4',7-di-(2-deoxy-α-l-fucopyranoside) (3) were isolated from the fermentation broth of strain 110B. The structures of the new compounds were determined by spectroscopic methods, including 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The result of medium-changing experiments implicated that these new compounds were microbial biotransformation products of strain M. aurantiaca 110B. The three compounds displayed moderate cytotoxic activity to the human lung carcinoma cell line A549, hepatocellular liver carcinoma cell line HepG2, and the human colon tumor cell line HCT116, whereas none of them showed antifungal or antibacterial activities. |
| 巻・号 | 17(5) |
| 公開日 | 2019-5-17 |
| DOI | 10.3390/md17050294 |
| PII | md17050294 |
| PMID | 31108876 |
| PMC | PMC6562861 |
| MeSH | A549 Cells Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology Cell Survival / drug effects* Glycosides / chemistry Glycosides / isolation & purification Glycosides / pharmacology HCT116 Cells Hep G2 Cells Humans Isoflavones / chemistry Micromonospora / chemistry* Soil Microbiology |
| IF | 3.772 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM21373 |