RRC ID 60880
Author Ghosal A, Sarkar P, Sundaram G.
Title Communication between Cyclin-dependent kinase Cdc2 and the Wis1-Spc1 MAPK pathway determines mitotic timing in Schizosaccharomyces pombe.
Journal Biol Open
Abstract Checkpoint activation and gene expression modulation represent key determinants of cellular survival in adverse conditions. The former is regulated by cyclin-dependent kinases (CDKs) while the latter can be controlled by mitogen-activated protein kinases (MAPKs). Association between cell-cycle progression and MAPK-dependent gene expression exists in cells growing in optimal environments. While MAPK-mediated regulation of the cell cycle is well characterised, the reciprocal influence of mitotic CDK on stress response is not well studied. We present evidence that CDK activity can regulate the extent of MAPK activation in Schizosaccharomyces pombe cells. We show that increasing or decreasing mitotic CDK (Cdc2) activity in S. pombe cells can affect the activation of stress responsive MAPK (Spc1) even in the absence of stress stimuli. Our results indicate that the strong correlation between Cdc2 activity and Spc1 MAPK-activity in S. pombe is important in regulating mitotic timing.This article has an associated First Person interview with the first author of the paper.
Volume 9(7)
Published 2020-7-21
DOI 10.1242/bio.053322
PII bio.053322
PMID 32554481
PMC PMC7390630
MeSH CDC2 Protein Kinase / metabolism* Gene Expression Regulation, Fungal Mitogen-Activated Protein Kinase Kinases / metabolism* Mitogen-Activated Protein Kinases / metabolism* Mitosis / physiology* Models, Biological Phosphorylation Schizosaccharomyces / physiology* Schizosaccharomyces pombe Proteins / metabolism* Signal Transduction* Stress, Physiological
IF 1.962
Yeast FY7283, FY8259, FY88258, FY10600, FY7708