| RRC ID |
61025
|
| 著者 |
Sato S, Li K, Sakurai N, Hashizume M, Baidya S, Nonaka H, Noguchi K, Ishikawa K, Obuse C, Takaoka A.
|
| タイトル |
Regulation of an adaptor protein STING by Hsp90β to enhance innate immune responses against microbial infections.
|
| ジャーナル |
Cell Immunol
|
| Abstract |
Stimulator of interferon genes (STING) plays important roles in the DNA-mediated innate immune responses. However, the regulatory mechanism of STING in terms of stabilization is not fully understood. Here, we identified the chaperone protein Hsp90s as novel STING interacting proteins. Treatment with an Hsp90 inhibitor 17-AAG and knockdown of Hsp90β but not Hsp90α reduced STING at protein level, resulted in the suppression of IFN induction in response to stimulation with cGAMP, and infections with HSV-1 and Listeria monocytogenes. Collectively, our results suggest that the control of STING protein by Hsp90β is a critical biological process in the DNA sensing pathways.
|
| 巻・号 |
356
|
| ページ |
104188
|
| 公開日 |
2020-10-1
|
| DOI |
10.1016/j.cellimm.2020.104188
|
| PII |
S0008-8749(20)30348-8
|
| PMID |
32763501
|
| MeSH |
Animals
DNA, Viral / immunology
HEK293 Cells
HSP90 Heat-Shock Proteins / immunology*
HSP90 Heat-Shock Proteins / metabolism
Herpesvirus 1, Human / genetics
Herpesvirus 1, Human / immunology
Humans
Immune Evasion / immunology
Immunity, Innate
Listeria monocytogenes / genetics
Listeria monocytogenes / immunology
Membrane Proteins / immunology*
Membrane Proteins / metabolism
Mice
RAW 264.7 Cells
Signal Transduction
Viral Proteins / metabolism
|
| IF |
4.078
|
| リソース情報 |
| ヒト・動物細胞 |
THP-1(RCB1189) |
