RRC ID 61144
Author Yamanashi Y, Fukushige S, Semba K, Sukegawa J, Miyajima N, Matsubara K, Yamamoto T, Toyoshima K.
Title The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.
Journal Mol Cell Biol
Abstract With v-yes DNA as the probe, a human cDNA library made from placental RNA was screened under relaxed conditions, and DNA clones derived from a novel genetic locus, termed lyn, were obtained. Nucleotide sequencing revealed that lyn could encode a novel tyrosine kinase that was very similar to mouse T-lymphocyte-specific tyrosine kinase p56lck and the v-yes protein as well as to the gene products of v-fgr and v-src. Northern hybridization analysis revealed that a 3.2-kilobase lyn mRNA was expressed in a variety of tissues of the human fetus. The pattern of lyn mRNA expression was different from those of related genes, such as yes and syn. Hybridization analysis of DNA from sorted chromosomes showed that the lyn gene is located on human chromosome 8 q13-qter.
Volume 7(1)
Pages 237-43
Published 1987-1-1
DOI 10.1128/mcb.7.1.237-243.1987
PMID 3561390
PMC PMC365062
MeSH Amino Acid Sequence Base Sequence Cell Line Cloning, Molecular DNA / metabolism Female Genes* Humans Placenta / enzymology Protein-Tyrosine Kinases / genetics* Proto-Oncogene Proteins c-yes Retroviridae Proteins / genetics* Retroviridae Proteins, Oncogenic*
IF 3.611
Resource
DNA material pLYP2.2 (RDB01275) Lyn/pLY30 (RDB01306) pME18S-Lyn (RDB01966)