論文 - 詳細
| RRC ID | 61180 |
|---|---|
| 著者 | Chen X, Meng Y, Wang Y, Du C, Yang C. |
| タイトル | A Biomimetic Material with a High Bio-responsibility for Bone Reconstruction and Tissue Engineering. |
| ジャーナル | J Biomater Sci Polym Ed |
| Abstract |
A biomimetic composite was prepared using type-I collagen as the matrix, and particles of sol-gel-derived bioactive glass (58S), hyaluronic acid and phosphatidylserine as additives. The material has an interconnected 3-D porous structure with a porosity > 85%. When incubated in simulated body fluid (SBF), the composite induced the formation of microcrystals of bone-like hydroxyapatite (HA), suggesting good bioactive properties. During the in vitro cell-culture experiment, MC3T3-E1 cells adhered to, migrated and spread on the surface of the porous composite. The material was employed to repair a 10-mm defect in a rabbit's radius. The composite was gradually degraded within 8 weeks and replaced by new bone. After 12 weeks, the bone marrow cavity was restored and the Haversian canal was noted from the histological observation. The biomimetic composite is a potential scaffold material for bone reconstruction and bone tissue engineering. |
| 巻・号 | 22(1-3) |
| ページ | 153-63 |
| 公開日 | 2011-1-1 |
| DOI | 10.1163/092050609X12583524936191 |
| PII | jbs3090 |
| PMID | 20546681 |
| MeSH | 3T3 Cells Absorbable Implants* Animals Biomimetic Materials* / chemistry Bone Regeneration Bone Substitutes* / chemistry Calcification, Physiologic Cell Adhesion Cell Movement Disease Models, Animal Durapatite / chemistry Glass* / chemistry Mice Microscopy, Electron, Scanning Porosity Rabbits Radius / injuries Spectrum Analysis Tissue Engineering / instrumentation Tissue Scaffolds* / chemistry X-Ray Diffraction |
| IF | 2.69 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |