| RRC ID |
61180
|
| 著者 |
Chen X, Meng Y, Wang Y, Du C, Yang C.
|
| タイトル |
A Biomimetic Material with a High Bio-responsibility for Bone Reconstruction and Tissue Engineering.
|
| ジャーナル |
J Biomater Sci Polym Ed
|
| Abstract |
A biomimetic composite was prepared using type-I collagen as the matrix, and particles of sol-gel-derived bioactive glass (58S), hyaluronic acid and phosphatidylserine as additives. The material has an interconnected 3-D porous structure with a porosity > 85%. When incubated in simulated body fluid (SBF), the composite induced the formation of microcrystals of bone-like hydroxyapatite (HA), suggesting good bioactive properties. During the in vitro cell-culture experiment, MC3T3-E1 cells adhered to, migrated and spread on the surface of the porous composite. The material was employed to repair a 10-mm defect in a rabbit's radius. The composite was gradually degraded within 8 weeks and replaced by new bone. After 12 weeks, the bone marrow cavity was restored and the Haversian canal was noted from the histological observation. The biomimetic composite is a potential scaffold material for bone reconstruction and bone tissue engineering.
|
| 巻・号 |
22(1-3)
|
| ページ |
153-63
|
| 公開日 |
2011-1-1
|
| DOI |
10.1163/092050609X12583524936191
|
| PII |
jbs3090
|
| PMID |
20546681
|
| MeSH |
3T3 Cells
Absorbable Implants*
Animals
Biomimetic Materials* / chemistry
Bone Regeneration
Bone Substitutes* / chemistry
Calcification, Physiologic
Cell Adhesion
Cell Movement
Disease Models, Animal
Durapatite / chemistry
Glass* / chemistry
Mice
Microscopy, Electron, Scanning
Porosity
Rabbits
Radius / injuries
Spectrum Analysis
Tissue Engineering / instrumentation
Tissue Scaffolds* / chemistry
X-Ray Diffraction
|
| IF |
2.69
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
