RRC ID 61266
Author Mizuno M, Fujisawa R, Kuboki Y.
Title Bone chondroadherin promotes attachment of osteoblastic cells to solid-state substrates and shows affinity to collagen.
Journal Calcif Tissue Int
Abstract Chondroadherin, which is reported to be synthesized by chondrocytes and to promote their attachment, was purified from bovine bone. It was a minor component of bone organic matrix, and was present in the 4 M guanidine extract of demineralized bone. Chondroadherin promoted attachment of osteoblastic cells to solid-state substrates, and bound to collagen. Binding of chondroadherin to collagen was significantly higher than that of osteonectin or decorin. These findings imply that chondroadherin may play a role in maintaining bone cells on the collagen matrices of bone.
Volume 59(3)
Pages 163-7
Published 1996-9-1
DOI 10.1007/s002239900103
PMID 8694892
MeSH Amino Acid Sequence Amino Acids / analysis Animals Blotting, Western Bone and Bones / chemistry* Bone and Bones / cytology Bone and Bones / metabolism Cattle Cell Adhesion Collagen / metabolism* Decorin Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay Extracellular Matrix Proteins / chemistry Extracellular Matrix Proteins / isolation & purification Extracellular Matrix Proteins / physiology* Molecular Sequence Data Molecular Weight Osteoblasts / cytology Osteoblasts / metabolism* Osteonectin / metabolism Protein Binding Proteoglycans / metabolism Serum Albumin, Bovine / metabolism
IF 3.423
Human and Animal Cells MC3T3-E1(RCB1126)