論文 - 詳細
RRC ID | 61266 |
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著者 | Mizuno M, Fujisawa R, Kuboki Y. |
タイトル | Bone chondroadherin promotes attachment of osteoblastic cells to solid-state substrates and shows affinity to collagen. |
ジャーナル | Calcif Tissue Int |
Abstract |
Chondroadherin, which is reported to be synthesized by chondrocytes and to promote their attachment, was purified from bovine bone. It was a minor component of bone organic matrix, and was present in the 4 M guanidine extract of demineralized bone. Chondroadherin promoted attachment of osteoblastic cells to solid-state substrates, and bound to collagen. Binding of chondroadherin to collagen was significantly higher than that of osteonectin or decorin. These findings imply that chondroadherin may play a role in maintaining bone cells on the collagen matrices of bone. |
巻・号 | 59(3) |
ページ | 163-7 |
公開日 | 1996-9-1 |
DOI | 10.1007/s002239900103 |
PMID | 8694892 |
MeSH | Amino Acid Sequence Amino Acids / analysis Animals Blotting, Western Bone and Bones / chemistry* Bone and Bones / cytology Bone and Bones / metabolism Cattle Cell Adhesion Collagen / metabolism* Decorin Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay Extracellular Matrix Proteins / chemistry Extracellular Matrix Proteins / isolation & purification Extracellular Matrix Proteins / physiology* Molecular Sequence Data Molecular Weight Osteoblasts / cytology Osteoblasts / metabolism* Osteonectin / metabolism Protein Binding Proteoglycans / metabolism Serum Albumin, Bovine / metabolism |
IF | 3.423 |
リソース情報 | |
ヒト・動物細胞 | MC3T3-E1(RCB1126) |