論文 - 詳細
| RRC ID | 61407 |
|---|---|
| 著者 | Nguyen MTT, Nguyen KDH, Dang PH, Nguyen HX, Awale S, Nguyen NT. |
| タイトル | Calosides A-F, Cardenolides from Calotropis gigantea and Their Cytotoxic Activity. |
| ジャーナル | J Nat Prod |
| Abstract |
Phytochemical analysis of the roots of Calotropis gigantea led to the isolation of six new cardenolide glycosides, calosides A-F (1-6), and five known cardenolides (7-11). The structures of 1-6 were elucidated based on NMR and ECD spectroscopic data interpretation. Caloside D (4) is the first naturally occurring example of a cardenolide containing a C-8/C-19 oxygen bridge. In turn, calosides E (5) and F (6) represent the first naturally occurring 3-epi-cannogenol diglycosides having potent cytotoxicity against the PANC-1 cell line (IC50, 0.081 and 0.070 μM, respectively) and HeLa (IC50, both 0.17 μM) cells, under normoglycemic conditions. |
| 巻・号 | 83(2) |
| ページ | 385-391 |
| 公開日 | 2020-2-28 |
| DOI | 10.1021/acs.jnatprod.9b00875 |
| PMID | 31967821 |
| MeSH | Antineoplastic Agents, Phytogenic / chemistry* Antineoplastic Agents, Phytogenic / pharmacology Calotropis / chemistry* Cardenolides / chemistry* Cardenolides / isolation & purification Cell Line, Tumor Glycosides / analysis* Glycosides / chemistry HeLa Cells Humans Molecular Structure Plant Roots / chemistry |
| IF | 3.782 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PANC-1(RCB2095) HeLa(RCB0007) |