| RRC ID |
61508
|
| Author |
Katsumata K, Ikeda H, Sato M, Ishizu A, Kawarada Y, Kato H, Wakisaka A, Koike T, Yoshiki T.
|
| Title |
Cytokine regulation of env gene expression of human endogenous retrovirus-R in human vascular endothelial cells.
|
| Journal |
Clin Immunol
|
| Abstract |
To determine whether human endogenous retroviruses are implicated in the pathogenesis of inflammatory vascular diseases of unknown etiology, we examined mRNA expression of a human endogenous retrovirus, HERV-R, which has a long open reading frame in the env region, in cultured human vascular endothelial and smooth muscle cells stimulated in the presence of various cytokines. mRNA of HERV-R was always evident in these cells but not in fibroblastic cells. Levels of expression in vascular endothelial cells were significantly regulated by treatment with tumor necrosis factor-alpha, interleukin (IL)-1alpha, and IL-1beta as up-regulators and interferon-gamma as a down-regulator. These observations are interpreted to mean that HERV-R expression may be up- or down-regulated at sites of inflammation in vessels in vivo and hence may play a pathogenetic role in inflammatory vascular diseases in humans, perhaps similar to endogenous retroviruses in mouse models of polyarteritis nodosa in humans.
|
| Volume |
93(1)
|
| Pages |
75-80
|
| Published |
1999-10-1
|
| DOI |
10.1006/clim.1999.4762
|
| PII |
S1521-6616(99)94762-9
|
| PMID |
10497013
|
| MeSH |
Cells, Cultured
Cytokines / pharmacology*
Endothelium, Vascular / cytology*
Endothelium, Vascular / metabolism
Gene Expression Regulation / drug effects
Genes, env / genetics*
Humans
Muscle, Smooth, Vascular / cytology
RNA, Messenger / metabolism
Retroviridae / genetics*
Reverse Transcriptase Polymerase Chain Reaction
|
| IF |
3.368
|
| Resource |
| Human and Animal Cells |
NB1RGB(RCB0222)
HUC-F(RCB0153) |
