論文 - 詳細
| RRC ID | 6151 |
|---|---|
| 著者 | Chikayama E, Sekiyama Y, Okamoto M, Nakanishi Y, Tsuboi Y, Akiyama K, Saito K, Shinozaki K, Kikuchi J. |
| タイトル | Statistical indices for simultaneous large-scale metabolite detections for a single NMR spectrum. |
| ジャーナル | Anal Chem |
| Abstract |
NMR-based metabolomics has become a practical and analytical methodology for discovering novel genes, biomarkers, metabolic phenotypes, and dynamic cell behaviors in organisms. Recent developments in NMR-based metabolomics, however, have not concentrated on improvements of comprehensiveness in terms of simultaneous large-scale metabolite detections. To resolve this, we have devised and implemented a statistical index, the SpinAssign p-value, in NMR-based metabolomics for large-scale metabolite annotation and publicized this information. It enables simultaneous annotation of more than 200 candidate metabolites from the single (13)C-HSQC (heteronuclear single quantum coherence) NMR spectrum of a single sample of cell extract. |
| 巻・号 | 82(5) |
| ページ | 1653-8 |
| 公開日 | 2010-3-1 |
| DOI | 10.1021/ac9022023 |
| PMID | 20128615 |
| MeSH | Metabolomics* Nuclear Magnetic Resonance, Biomolecular / methods* |
| IF | 6.785 |
| 引用数 | 89 |
| WOS 分野 | CHEMISTRY, ANALYTICAL |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| シロイヌナズナ / 植物培養細胞・遺伝子 | rpc00008 |