論文 - 詳細
| RRC ID | 61529 |
|---|---|
| 著者 | Haniu H, Saito N, Matsuda Y, Kim YA, Park KC, Tsukahara T, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H. |
| タイトル | Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines. |
| ジャーナル | Int J Nanomedicine |
| Abstract |
We examined differences in cellular responses to multi-walled carbon nanotubes (MWCNTs) using malignant pleural mesothelioma cells (MESO-1), bronchial epithelial cells (BEAS-2B), neuroblastoma cells (IMR-32), and monoblastic cells (THP-1), before and after differentiation. MESO-1, BEAS-2B and differentiated THP-1 cells actively endocytosed MWCNTs, resulting in cytotoxicity with lysosomal injury. However, cytotoxicity did not occur in IMR-32 or undifferentiated THP-1 cells. Both differentiated and undifferentiated THP-1 cells exhibited an inflammatory response. Carbon blacks were endocytosed by the same cell types without lysosomal damage and caused cytokine secretion, but they did not cause cytotoxicity. These results indicate that the cytotoxicity of MWCNTs requires not only cellular uptake but also lysosomal injury. Furthermore, it seems that membrane permeability or cytokine secretion without cytotoxicity results from several active mechanisms. Clarification of the cellular recognition mechanism for MWCNTs is important for developing safer MWCNTs. |
| 巻・号 | 6 |
| ページ | 3487-97 |
| 公開日 | 2011-1-1 |
| DOI | 10.2147/IJN.S26689 |
| PII | ijn-6-3487 |
| PMID | 22267932 |
| PMC | PMC3260041 |
| MeSH | Cell Line, Transformed Cell Line, Tumor Cell Survival / drug effects Cytokines / metabolism Endocytosis Humans Nanotubes, Carbon / chemistry* Nanotubes, Carbon / toxicity Reactive Oxygen Species / metabolism |
| IF | 5.115 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Youtube |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ACC-MESO-1(RCB2292) THP-1(RCB1189) |