RRC ID 61543
Author Namiki Y, Namiki T, Date M, Yanagihara K, Yashiro M, Takahashi H.
Title Enhanced photodynamic antitumor effect on gastric cancer by a novel photosensitive stealth liposome.
Journal Pharmacol Res
Abstract Lipophilic photosensitizers hold potential for cancer photodynamic therapy. We sought to develop a novel photosensitive stealth liposome (PSSL) which incorporating a lipophilic photosensitizer into its lipid bilayer and to examine its photoactivity. We prepared PSSL composed of lipophilic chlorin e6 (Ce6) ester, dilauroylphosphatidylcholine, dioleoylphosphatidylethanolamine and distearoyl-phosphoethanolamine-N-[poly (ethylene glycol) 2000] and evaluated its photodynamic effect against gastric cancer cell lines and tumor-bearing nude mice models. In gastric cancer cell lines, LC(80) of PSSL was a maximum of 53 times as low as that of Ce6 sodium salt (Ce6-Na). PSSL completely destroyed all tumors in animal models and tumor recurrence levels were minimal (1.5 +/- 0.9%). PSSL achieved greater photodynamic effects in gastric cancer cell lines and in murine models than Ce6-Na. PSSL holds promise for photodynamic therapy for gastric cancer.
Volume 50(1)
Pages 65-76
Published 2004-7
DOI 10.1016/j.phrs.2003.12.015
PII S1043661803004225
PMID 15082031
MeSH Animals Cell Line, Tumor Drug Carriers Lasers Lipid Bilayers Liposomes Mice Mice, Nude Microscopy, Fluorescence Neoplasm Transplantation Photochemotherapy* Photosensitizing Agents / administration & dosage* Photosensitizing Agents / pharmacokinetics Photosensitizing Agents / therapeutic use* Spectrophotometry, Ultraviolet Stomach Neoplasms / pathology Stomach Neoplasms / therapy* Tissue Distribution
Human and Animal Cells MKN45(RCB1001) MKN74(RCB1002) MKN7(RCB0999)