| RRC ID |
61567
|
| 著者 |
Kokuryo D, Aoki I, Yuba E, Kono K, Aoshima S, Kershaw J, Saga T.
|
| タイトル |
Evaluation of a combination tumor treatment using thermo-triggered liposomal drug delivery and carbon ion irradiation.
|
| ジャーナル |
Transl Res
|
| Abstract |
The combination of radiotherapy with chemotherapy is one of the most promising strategies for cancer treatment. Here, a novel combination strategy utilizing carbon ion irradiation as a high-linear energy transfer (LET) radiotherapy and a thermo-triggered nanodevice is proposed, and drug accumulation in the tumor and treatment effects are evaluated using magnetic resonance imaging relaxometry and immunohistology (Ki-67, n = 15). The thermo-triggered liposomal anticancer nanodevice was administered into colon-26 tumor-grafted mice, and drug accumulation and efficacy was compared for 6 groups (n = 32) that received or did not receive the radiotherapy and thermo trigger. In vivo quantitative R1 maps visually demonstrated that the multimodal thermosensitive polymer-modified liposomes (MTPLs) can accumulate in the tumor tissue regardless of whether the region was irradiated by carbon ions or not. The tumor volume after combination treatment with carbon ion irradiation and MTPLs with thermo-triggering was significantly smaller than all the control groups at 8 days after treatment. The proposed strategy of combining high-LET irradiation and the nanodevice provides an effective approach for minimally invasive cancer treatment.
|
| 巻・号 |
185
|
| ページ |
24-33
|
| 公開日 |
2017-7-1
|
| DOI |
10.1016/j.trsl.2017.04.001
|
| PII |
S1931-5244(17)30165-2
|
| PMID |
28482173
|
| MeSH |
Animals
Antineoplastic Agents / administration & dosage
Antineoplastic Agents / therapeutic use*
Carbon
Cell Line, Tumor
Chemoradiotherapy*
Colonic Neoplasms / therapy*
Doxorubicin / administration & dosage
Doxorubicin / therapeutic use*
Drug Delivery Systems
Female
Hot Temperature
Liposomes / chemistry*
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasms, Experimental / therapy*
Radiotherapy
|
| IF |
5.411
|
| リソース情報 |
| ヒト・動物細胞 |
Colon-26(RCB2657) |
