| RRC ID |
61576
|
| 著者 |
Rojas A, González I, Rodríguez B, Romero J, Figueroa H, Llanos J, Morales E, Pérez-Castro R.
|
| タイトル |
Evidence of involvement of the receptor for advanced glycation end-products (RAGE) in the adhesion of Helicobacter pylori to gastric epithelial cells.
|
| ジャーナル |
Microbes Infect
|
| Abstract |
The adherence of Helicobacter pylori to gastric epithelial cells is required for prolonged persistence in the stomach and for induction of injury. Here, we first reported a new role of the receptor for advanced glycation end-products (RAGE) on the adherence of H. pylori to gastric epithelial cells, assessed by different methods and binding to immobilized RAGE. RAGE-targeted knock-down in MKN74 cell line markedly reduced not only the adhesion of H. pylori, but also the levels of IL-8 transcripts and protein released in response to infection. These data suggest that RAGE may represent a new factor on the pathogenesis of H. pylori infection.
|
| 巻・号 |
13(10)
|
| ページ |
818-23
|
| 公開日 |
2011-9-1
|
| DOI |
10.1016/j.micinf.2011.04.005
|
| PII |
S1286-4579(11)00113-4
|
| PMID |
21609778
|
| MeSH |
Bacterial Adhesion*
Cell Line, Tumor
Epithelial Cells / microbiology*
Gene Expression Profiling
Gene Knockdown Techniques
Helicobacter pylori / pathogenicity*
Host-Pathogen Interactions*
Humans
Interleukin-8 / biosynthesis
Receptor for Advanced Glycation End Products
Receptors, Immunologic / metabolism*
|
| IF |
2.373
|
| リソース情報 |
| ヒト・動物細胞 |
LM8(RCB1450)
Saos-2(RCB0428) |
