RRC ID 61576
Author Rojas A, González I, Rodríguez B, Romero J, Figueroa H, Llanos J, Morales E, Pérez-Castro R.
Title Evidence of involvement of the receptor for advanced glycation end-products (RAGE) in the adhesion of Helicobacter pylori to gastric epithelial cells.
Journal Microbes Infect
Abstract The adherence of Helicobacter pylori to gastric epithelial cells is required for prolonged persistence in the stomach and for induction of injury. Here, we first reported a new role of the receptor for advanced glycation end-products (RAGE) on the adherence of H. pylori to gastric epithelial cells, assessed by different methods and binding to immobilized RAGE. RAGE-targeted knock-down in MKN74 cell line markedly reduced not only the adhesion of H. pylori, but also the levels of IL-8 transcripts and protein released in response to infection. These data suggest that RAGE may represent a new factor on the pathogenesis of H. pylori infection.
Volume 13(10)
Pages 818-23
Published 2011-9-1
DOI 10.1016/j.micinf.2011.04.005
PII S1286-4579(11)00113-4
PMID 21609778
MeSH Bacterial Adhesion* Cell Line, Tumor Epithelial Cells / microbiology* Gene Expression Profiling Gene Knockdown Techniques Helicobacter pylori / pathogenicity* Host-Pathogen Interactions* Humans Interleukin-8 / biosynthesis Receptor for Advanced Glycation End Products Receptors, Immunologic / metabolism*
IF 2.373
Human and Animal Cells LM8(RCB1450) Saos-2(RCB0428)