RRC ID 61625
著者 Wang Y, Liu X, Zhu L, Li W, Li Z, Lu X, Liu J, Hua W, Zhou Y, Gu Y, Zhu M.
タイトル PG545 alleviates diabetic retinopathy by promoting retinal Müller cell autophagy to inhibit the inflammatory response.
ジャーナル Biochem Biophys Res Commun
Abstract Diabetic retinopathy (DR), a major cause of blindness in working-age people, is attributed to the inflammatory response of retinal Müller cells (RMCs). The heparanase inhibitor PG545 plays proautophagic and anti-inflammatory roles. Intraperitoneal injection of PG545 at a dose of 20 mg/kg/d clearly reduced diabetes-induced body weight changes and fasting blood glucose levels in mice. PG545 also mitigated the reduction in retinal thickness and the formation of microaneurysms by promoting autophagy to inhibit the inflammatory response. In vitro, PG545 stimulated autophagy to downregulate the inflammatory response in high glucose-induced primary adult mouse RMCs. These data suggest that PG545 mitigates DR by promoting RMC autophagy to inhibit the inflammatory response.
巻・号 531(4)
ページ 452-458
公開日 2020-10-22
DOI 10.1016/j.bbrc.2020.07.134
PII S0006-291X(20)31535-7
PMID 32800548
MeSH Animals Autophagy / drug effects Autophagy-Related Protein 7 / genetics Blood Glucose / metabolism Body Weight Cells, Cultured Diabetes Mellitus, Experimental / complications Diabetes Mellitus, Experimental / drug therapy Diabetic Retinopathy / drug therapy* Diabetic Retinopathy / pathology Ependymoglial Cells / drug effects* Ependymoglial Cells / pathology Glucose / pharmacology Male Mice, Inbred C57BL Mice, Mutant Strains Retinitis / drug therapy* Retinitis / pathology Saponins / pharmacology*
IF 2.985
リソース情報
実験動物マウス RBRC02759