| RRC ID |
61692
|
| Author |
Ko EK, Jeong SI, Lee JH, Shin H.
|
| Title |
Improvement of differentiation and mineralization of pre-osteoblasts on composite nanofibers of poly(lactic acid) and nanosized bovine bone powder.
|
| Journal |
Macromol Biosci
|
| Abstract |
The effect of NBM incorporation in PLA nanofibers on their mechanical properties and the differentiation and mineralization of osteoblasts was studied. At 20% NBM, the Young's modulus of the nanofibers was 37.78 +/- 4.23, significantly larger than that of pure PLA nanofibers. MC3T3-E1 pre-osteoblasts attached to both types of nanofibers and developed full osteogenic phenotypes. A profound effect of NBM on the mineralization of MC3T3-E1 pre-osteoblasts was confirmed, suggesting that NBM/PLA composite nanofibers exhibit properties similar to those of the native collagen-rich mineralized bone matrix, and could therefore serve as a temporary substrate for facilitating the differentiation and mineralization of bone-forming cells.
|
| Volume |
8(12)
|
| Pages |
1098-107
|
| Published |
2008-12-8
|
| DOI |
10.1002/mabi.200800089
|
| PMID |
18781556
|
| MeSH |
3T3 Cells
Animals
Base Sequence
Bone and Bones / chemistry*
Calcification, Physiologic*
Cattle
DNA Primers
Lactic Acid / chemistry*
Materials Testing
Mice
Microscopy, Atomic Force
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Nanostructures*
Osteoblasts / chemistry*
Polyesters
Polymers / chemistry*
Powders
Reverse Transcriptase Polymerase Chain Reaction
Spectroscopy, Fourier Transform Infrared
Tissue Engineering
|
| IF |
3.416
|
| Resource |
| Human and Animal Cells |
MC3T3-E1(RCB1126) |
