RRC ID 61694
著者 Paterson SM, Shadforth AM, Shaw JA, Brown DH, Chirila TV, Baker MV.
タイトル Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: the use of copolymerization as a means to functionalize PHEMA sponges.
ジャーナル Mater Sci Eng C Mater Biol Appl
Abstract A monomer that contained the RGD ligand motif was synthesized and copolymerized with 2-hydroxyethyl methacrylate using polymerization-induced phase separation methods to form poly(2-hydroxyethyl methacrylate)-based hydrogel sponges. The sponges had morphologies of aggregated polymer droplets and interconnected pores, the pores having dimensions in the order of 10 μm typical of PHEMA sponges. RGD-containing moieties appeared to be evenly distributed through the polymer droplets. Compared to PHEMA sponges that were not functionalized with RGD, the new sponges containing RGD allowed greater invasion by human corneal epithelial cells, by advancing the attachment of cells to the surface of the polymer droplets.
巻・号 33(8)
ページ 4917-22
公開日 2013-12-1
DOI 10.1016/j.msec.2013.08.011
PII S0928-4931(13)00474-8
PMID 24094205
MeSH Biocompatible Materials / chemistry* Biocompatible Materials / pharmacology Cell Adhesion / drug effects Cells, Cultured Epithelial Cells / cytology Humans Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry Hydrogel, Polyethylene Glycol Dimethacrylate / pharmacology Ligands Microscopy, Electron, Transmission Oligopeptides / chemistry* Polyhydroxyethyl Methacrylate / chemistry*
IF 5.88
リソース情報
ヒト・動物細胞 HCE-T(RCB2280)