Reference - Detail
| RRC ID | 61750 |
|---|---|
| Author | Seong KH, Ly NH, Katou Y, Yokota N, Nakato R, Murakami S, Hirayama A, Fukuda S, Kang S, Soga T, Shirahige K, Ishii S. |
| Title | Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells. |
| Journal | Commun Biol |
| Abstract |
Paternal environmental factors can epigenetically influence gene expressions in offspring. We demonstrate that restraint stress, an experimental model for strong psychological stress, to fathers affects the epigenome, transcriptome, and metabolome of offspring in a MEKK1-dATF2 pathway-dependent manner in Drosophila melanogaster. Genes involved in amino acid metabolism are upregulated by paternal restraint stress, while genes involved in glycolysis and the tricarboxylic acid (TCA) cycle are downregulated. The effects of paternal restraint stress are also confirmed by metabolome analysis. dATF-2 is highly expressed in testicular germ cells, and restraint stress also induces p38 activation in the testes. Restraint stress induces Unpaired 3 (Upd3), a Drosophila homolog of Interleukin 6 (IL-6). Moreover, paternal overexpression of upd3 in somatic cells disrupts heterochromatin in offspring but not in offspring from dATF-2 mutant fathers. These results indicate that paternal restraint stress affects metabolism in offspring via inheritance of dATF-2-dependent epigenetic changes. |
| Volume | 3(1) |
| Pages | 208 |
| Published | 2020-5-4 |
| DOI | 10.1038/s42003-020-0935-z |
| PII | 10.1038/s42003-020-0935-z |
| PMID | 32367035 |
| PMC | PMC7198565 |
| MeSH | Activating Transcription Factor 2 / genetics* Activating Transcription Factor 2 / metabolism Animals Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Epigenome* Fathers Germ Cells / physiology* MAP Kinase Kinase Kinase 1 / physiology Male Metabolome* Signal Transduction / physiology Transcriptome* |
| IF | 4.165 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 7 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC118672 DGRC118673 DGRC118674 |