論文 - 詳細
| RRC ID | 61802 |
|---|---|
| 著者 | Tomita M, Maeda M. |
| タイトル | Mechanisms and biological importance of photon-induced bystander responses: do they have an impact on low-dose radiation responses. |
| ジャーナル | J Radiat Res |
| Abstract |
Elucidating the biological effect of low linear energy transfer (LET), low-dose and/or low-dose-rate ionizing radiation is essential in ensuring radiation safety. Over the past two decades, non-targeted effects, which are not only a direct consequence of radiation-induced initial lesions produced in cellular DNA but also of intra- and inter-cellular communications involving both targeted and non-targeted cells, have been reported and are currently defining a new paradigm in radiation biology. These effects include radiation-induced adaptive response, low-dose hypersensitivity, genomic instability, and radiation-induced bystander response (RIBR). RIBR is generally defined as a cellular response that is induced in non-irradiated cells that receive bystander signals from directly irradiated cells. RIBR could thus play an important biological role in low-dose irradiation conditions. However, this suggestion was mainly based on findings obtained using high-LET charged-particle radiations. The human population (especially the Japanese, who are exposed to lower doses of radon than the world average) is more frequently exposed to low-LET photons (X-rays or γ-rays) than to high-LET charged-particle radiation on a daily basis. There are currently a growing number of reports describing a distinguishing feature between photon-induced bystander response and high-LET RIBR. In particular, photon-induced bystander response is strongly influenced by irradiation dose, the irradiated region of the targeted cells, and p53 status. The present review focuses on the photon-induced bystander response, and discusses its impact on the low-dose radiation effect. |
| 巻・号 | 56(2) |
| ページ | 205-19 |
| 公開日 | 2015-3-1 |
| DOI | 10.1093/jrr/rru099 |
| PII | rru099 |
| PMID | 25361549 |
| PMC | PMC4380047 |
| MeSH | Animals Bystander Effect / physiology* Bystander Effect / radiation effects* Dose-Response Relationship, Radiation Humans Linear Energy Transfer / physiology* Linear Energy Transfer / radiation effects Models, Biological* Photons* Radiation Dosage Tumor Suppressor Protein p53 / metabolism* |
| IF | 1.95 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | NB1RGB(RCB0222) |