論文 - 詳細
| RRC ID | 62000 |
|---|---|
| 著者 | Nakano T, Okaie Y, Kinugasa Y, Koujin T, Suda T, Hiraoka Y, Haraguchi T. |
| タイトル | Roles of Remote and Contact Forces in Epithelial Cell Structure Formation. |
| ジャーナル | Biophys J |
| Abstract |
Cancer cells collectively form a large-scale structure for their growth. In this article, we report that HeLa cells, epithelial-like human cervical cancer cells, aggressively migrate on Matrigel and form a large-scale structure in a cell-density-dependent manner. To explain the experimental results, we develop a simple model in which cells interact and migrate using the two fundamentally different types of force, remote and contact forces, and show how cells form a large-scale structure. We demonstrate that the simple model reproduces experimental observations, suggesting that the remote and contact forces considered in this work play a major role in large-scale structure formation of HeLa cells. This article provides important evidence that cancer cells form a large-scale structure and develops an understanding into the poorly understood mechanisms of their structure formation. |
| 巻・号 | 118(6) |
| ページ | 1466-1478 |
| 公開日 | 2020-3-24 |
| DOI | 10.1016/j.bpj.2020.01.037 |
| PII | S0006-3495(20)30112-0 |
| PMID | 32097624 |
| PMC | PMC7091513 |
| MeSH | Cell Count Epithelial Cells* HeLa Cells Humans |
| IF | 3.854 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 15 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa |