| RRC ID |
62013
|
| 著者 |
Tamaki N, Kuno A, Matsuda A, Tsujikawa H, Yamazaki K, Yasui Y, Tsuchiya K, Nakanishi H, Itakura J, Korenaga M, Mizokami M, Kurosaki M, Sakamoto M, Narimatsu H, Izumi N.
|
| タイトル |
Serum Wisteria Floribunda Agglutinin-Positive Sialylated Mucin 1 as a Marker of Progenitor/Biliary Features in Hepatocellular Carcinoma.
|
| ジャーナル |
Sci Rep
|
| Abstract |
Histological molecular classification of hepatocellular carcinoma (HCC) is clinically important for predicting the prognosis. However, a reliable serum marker has not been established. The aim of this study was to evaluate the diagnostic value of serum Wisteria Floribunda agglutinin-positive sialylated mucin 1 (WFA-sialylated MUC1), which is a novel biliary marker, as a marker of HCC with hepatic progenitor cell (HPC)/biliary features and of prognosis. A total of 144 consecutive patients who underwent complete radiofrequency ablation of primary HCC were enrolled. A serum WFA-sialylated MUC1 level of 900 μL/mL was determined as the optimal cutoff value for prediction of immunohistochemical staining for HPC/biliary features [sialylated MUC1 and cytokeratin 19 (CK19)]. Positive staining rate of sialylated MUC1 and CK19 was significantly higher in patients with WFA-sialylated MUC1 ≥900 than those with WFA-sialylated MUC1 <900. Furthermore, cumulative incidence of HCC recurrence was significantly higher in patients with WFA-sialylated MUC1 ≥900 and on multivariate analysis, serum WFA-sialylated MUC1 levels was an independent predictor of HCC recurrence. These results revealed that serum WFA-sialylated MUC1 was associated with histological feature of HCC and recurrence after curative therapy and it could be a novel marker of HPC/biliary features in HCC and of prognosis.
|
| 巻・号 |
7(1)
|
| ページ |
244
|
| 公開日 |
2017-3-21
|
| DOI |
10.1038/s41598-017-00357-8
|
| PII |
10.1038/s41598-017-00357-8
|
| PMID |
28325920
|
| PMC |
PMC5428232
|
| MeSH |
Aged
Biomarkers / blood*
Carcinoma, Hepatocellular / diagnosis*
Carcinoma, Hepatocellular / pathology*
Carcinoma, Hepatocellular / therapy
Female
Histocytochemistry
Humans
Keratin-19 / analysis
Liver / pathology
Male
Middle Aged
Mucin-1 / blood*
Plant Lectins / blood*
Prognosis
Receptors, N-Acetylglucosamine / blood*
Recurrence
Serum / chemistry*
|
| IF |
3.998
|
| リソース情報 |
| ヒト・動物細胞 |
TGBC1TKB(RCB1129) |
