Reference - Detail
| RRC ID | 62026 |
|---|---|
| Author | Narimatsu S, Kobayashi N, Masubuchi Y, Horie T, Kakegawa T, Kobayashi H, Hardwick JP, Gonzalez FJ, Shimada N, Ohmori S, Kitada M, Asaoka K, Kataoka H, Yamamoto S, Satoh T. |
| Title | Species difference in enantioselectivity for the oxidation of propranolol by cytochrome P450 2D enzymes. |
| Journal | Chem Biol Interact |
| Abstract |
We examined and compared enantioselectivity in the oxidation of propranolol (PL) by liver microsomes from humans and Japanese monkeys (Macaca fuscata). PL was oxidized at the naphthalene ring to 4-hydroxypropranolol, 5-hydroxypropranolol and side chain N-desisopropylpropranolol by human liver microsomes with enantioselectivity of [R(+)>S(-)] in PL oxidation rates at substrate concentrations of 10 microM and 1 mM. In contrast, reversed enantioselectivity [R(+) |
| Volume | 127(1) |
| Pages | 73-90 |
| Published | 2000-6-15 |
| DOI | 10.1016/s0009-2797(00)00174-5 |
| PII | S0009-2797(00)00174-5 |
| PMID | 10903420 |
| MeSH | Animals Baculoviridae / genetics Cytochrome P-450 CYP2D6 / genetics Cytochrome P-450 CYP2D6 / metabolism* Humans Hydroxylation Kinetics Macaca Microsomes, Liver / enzymology* Oxidation-Reduction Propranolol / chemistry* Propranolol / metabolism* Recombinant Proteins / metabolism Species Specificity Spodoptera / metabolism Stereoisomerism* Substrate Specificity Transfection |
| IF | 3.723 |
| Resource | |
| Human and Animal Cells | Sf9(RCB0563) |