論文 - 詳細
| RRC ID | 62040 |
|---|---|
| 著者 | Yamada A, Kawano K, Harashima N, Niiya F, Nagai K, Kobayashi T, Mine T, Ushijima K, Nishida T, Itoh K. |
| タイトル | Study of HLA class I restriction and the directed antigens of cytotoxic T lymphocytes at the tumor sites of ovarian cancer. |
| ジャーナル | Cancer Immunol Immunother |
| Abstract |
The molecular basis of T-cell-mediated recognition of ovarian cancer cells remains to be fully addressed. In this study we investigated HLA class I restriction and directed antigens of cytotoxic T lymphocytes (CTL) at the sites of ovarian cancer. Three HLA-class-I-restricted CTL lines were established from the tumor sites of ovarian cancer by culturing tumor-infiltrating lymphocytes or tumor-associated ascitic lymphocytes with interleukin-2: (1) HLA-A2402-restricted and ovarian-adenocarcinoma-specific CTL, (2) HLA-A2-restricted CTL recognizing histologically different cancers, and (3) HLA-B52-restricted and ovarian-cancer-specific CTL. HLA-A0201, HLA-A0206 and HLA-A0207 tumor cells were lysed by the HLA-A2-restricted CTL. HLA-B52 restriction of the third CTL line was confirmed by the transfection of HLA-B5201 cDNA into the tumor cells. The HLA-A2-restricted CTL recognized the SART-1, but not the MAGE-1 or MAGE-3 antigen. These results may facilitate a better understanding of the molecular basis of tumor-specific immunity at the tumor site of ovarian cancer. |
| 巻・号 | 48(2-3) |
| ページ | 147-52 |
| 公開日 | 1999-1-1 |
| DOI | 10.1007/s002620050559 |
| PMID | 10414469 |
| MeSH | Animals Antigens, Neoplasm / immunology* COS Cells Female Histocompatibility Antigens Class I / physiology* Humans Interferon-gamma / biosynthesis Melanoma-Specific Antigens Neoplasm Proteins / immunology Ovarian Neoplasms / immunology* Ribonucleoproteins, Small Nuclear* T-Lymphocytes, Cytotoxic / immunology* Tumor Cells, Cultured |
| IF | 5.442 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | OMC-3(RCB0755) HTOA(RCB0692) |