論文 - 詳細
| RRC ID | 62081 |
|---|---|
| 著者 | Nakano K, Todo T, Chijiiwa K, Tanaka M. |
| タイトル | Therapeutic efficacy of G207, a conditionally replicating herpes simplex virus type 1 mutant, for gallbladder carcinoma in immunocompetent hamsters. |
| ジャーナル | Mol Ther |
| Abstract |
Gallbladder cancer is an extremely difficult disease to cure once metastases occur. In this paper, we explored the potential of G207, an oncolytic, replication-competent herpes simplex virus type 1 mutant, as a new therapeutic means for gallbladder cancer. Gallbladder carcinoma cell lines (four human and one hamster) showed nearly total cell killing within 72 h of G207 infection at a m.o.i. of 0.25 to 2.5 in vitro. The susceptibility to G207 cytopathic activity correlated with the infection efficiency demonstrated by lacZ expression. Intraneoplastic inoculation of G207 (1 x 10(7) pfu) in immunocompetent hamsters bearing established subcutaneous KIGB-5 tumors caused a significant inhibition of tumor growth and prolongation of survival. Repeated inoculations (three times with 4-day intervals) were significantly more efficacious than a single inoculation. In hamsters with bilateral subcutaneous KIGB-5 tumors, inoculation of one tumor alone with G207 caused regression or growth reduction of uninoculated tumors as well as inoculated tumors. In athymic mice, however, the anti-tumor effect was largely reduced in inoculated tumors and completely abolished in remote tumors, suggesting large contribution of T-cell-mediated immune responses to both local and systemic anti-tumor effect of G207. These results indicate that G207 may be useful as a new strategy for gallbladder cancer treatment. |
| 巻・号 | 3(4) |
| ページ | 431-7 |
| 公開日 | 2001-4-1 |
| DOI | 10.1006/mthe.2001.0303 |
| PII | S1525-0016(01)90303-X |
| PMID | 11319903 |
| MeSH | Animals Carcinoma / therapy* Cell Line Cricetinae Female Gallbladder Neoplasms / therapy* Genetic Therapy / methods* Genetic Vectors / genetics Herpesvirus 1, Human / genetics* Mesocricetus Mice Mice, Nude Mutation* Time Factors Tumor Cells, Cultured |
| IF | 8.986 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | TGBC1TKB(RCB1129) TGBC2TKB(RCB1130) |