| RRC ID |
62103
|
| Author |
Zhang BN, Watanabe S, Kohyama M, Saijo K, Kusakabe M, Ohno T.
|
| Title |
Tumor formation suppressed in gammadeltaT knock-out mice.
|
| Journal |
Cancer Lett
|
| Abstract |
Tumor formation was examined in mice in which the beta-chain gene of alphabetaT was knocked out (alphabetaT-KO mice) or the delta-chain gene of gammadeltaT was knocked out (gammadeltaT-KO mice). Development of Hepa 1-6 cell hepatoma was observed in six of six alphabetaT-KO mice, in four of six wild-type mice, and in only one of six gammadeltaT-KO mice. These results imply that gammadeltaT cells play a role in suppression of killer cell activity in tumor-bearing mice.
|
| Volume |
153(1-2)
|
| Pages |
63-6
|
| Published |
2000-5-29
|
| DOI |
10.1016/s0304-3835(00)00343-8
|
| PII |
S0304383500003438
|
| PMID |
10779631
|
| MeSH |
Animals
Carcinoma, Hepatocellular / genetics
Carcinoma, Hepatocellular / immunology*
Cell Transformation, Neoplastic / genetics
Female
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Neoplasm Transplantation
Receptors, Antigen, T-Cell, gamma-delta / genetics
Receptors, Antigen, T-Cell, gamma-delta / physiology*
T-Lymphocytes / immunology
T-Lymphocytes / physiology*
Tumor Cells, Cultured
|
| IF |
7.36
|
| Resource |
| Human and Animal Cells |
Hepa 1-6(RCB1638) |
