RRC ID 62106
著者 Hatano H, Takekawa F, Hashimoto K, Ishihara M, Kawase M, Qing C, Qin-Tao W, Sakagami H.
タイトル Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines.
ジャーナル Anticancer Res
Abstract The tumor-specific cytotoxicity and the type of cell death induced by thirty-eight newly synthesized tetrahydroisoquinoline derivatives in human oral squamous cell carcinoma cell lines were investigated. 6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(3,4-dimethoxyphenyl) methanone that has bulky substituents (such as 3,4-dimethoxybenzoyl group) (TQ9) and ethyl 2-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylate that has ethoxycarbonyl group and benzyloxycarbonyl group (TD13) showed the highest tumor-specific cytotoxicity (TS=12.5 and 5.3, respectively). This supports the importance of molecular size for the cytotoxicity induction. TQ9 induced internulceosomal DNA fragmentation and caspase-3 activation only marginally in HL-60 cells, whereas it enhanced the formation of acidic organelles (stained with acridine orange) without induction of DNA fragmentation or caspase-3 activation in human squamous cell carcinoma cell lines (HSC-2, HSC-4), suggesting the induction of autophagy in the latter cells.
巻・号 29(8)
ページ 3079-86
公開日 2009-8-1
PII 29/8/3079
PMID 19661319
MeSH Apoptosis / drug effects* Autophagy Carcinoma, Squamous Cell / drug therapy* Carcinoma, Squamous Cell / pathology* Caspase 3 / metabolism Enzyme Activation / drug effects Humans Mouth Neoplasms / drug therapy* Mouth Neoplasms / pathology* Organelles / drug effects Tetrahydroisoquinolines / chemistry* Tetrahydroisoquinolines / pharmacology* Tumor Cells, Cultured
IF 1.994
リソース情報
ヒト・動物細胞 HSC-4(RCB1902) HSC-2(RCB1945) HSC-3(RCB1975)