論文 - 詳細
| RRC ID | 62106 |
|---|---|
| 著者 | Hatano H, Takekawa F, Hashimoto K, Ishihara M, Kawase M, Qing C, Qin-Tao W, Sakagami H. |
| タイトル | Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines. |
| ジャーナル | Anticancer Res |
| Abstract |
The tumor-specific cytotoxicity and the type of cell death induced by thirty-eight newly synthesized tetrahydroisoquinoline derivatives in human oral squamous cell carcinoma cell lines were investigated. 6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(3,4-dimethoxyphenyl) methanone that has bulky substituents (such as 3,4-dimethoxybenzoyl group) (TQ9) and ethyl 2-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylate that has ethoxycarbonyl group and benzyloxycarbonyl group (TD13) showed the highest tumor-specific cytotoxicity (TS=12.5 and 5.3, respectively). This supports the importance of molecular size for the cytotoxicity induction. TQ9 induced internulceosomal DNA fragmentation and caspase-3 activation only marginally in HL-60 cells, whereas it enhanced the formation of acidic organelles (stained with acridine orange) without induction of DNA fragmentation or caspase-3 activation in human squamous cell carcinoma cell lines (HSC-2, HSC-4), suggesting the induction of autophagy in the latter cells. |
| 巻・号 | 29(8) |
| ページ | 3079-86 |
| 公開日 | 2009-8-1 |
| PII | 29/8/3079 |
| PMID | 19661319 |
| MeSH | Apoptosis / drug effects* Autophagy Carcinoma, Squamous Cell / drug therapy* Carcinoma, Squamous Cell / pathology* Caspase 3 / metabolism Enzyme Activation / drug effects Humans Mouth Neoplasms / drug therapy* Mouth Neoplasms / pathology* Organelles / drug effects Tetrahydroisoquinolines / chemistry* Tetrahydroisoquinolines / pharmacology* Tumor Cells, Cultured |
| IF | 1.994 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HSC-4(RCB1902) HSC-2(RCB1945) HSC-3(RCB1975) |