| RRC ID |
62198
|
| 著者 |
Simon CG Jr, Yang Y, Dorsey SM, Ramalingam M, Chatterjee K.
|
| タイトル |
3D polymer scaffold arrays.
|
| ジャーナル |
Methods Mol Biol
|
| Abstract |
We have developed a combinatorial platform for fabricating tissue scaffold arrays that can be used for screening cell-material interactions. Traditional research involves preparing samples one at a time for characterization and testing. Combinatorial and high-throughput (CHT) methods lower the cost of research by reducing the amount of time and material required for experiments by combining many samples into miniaturized specimens. In order to help accelerate biomaterials research, many new CHT methods have been developed for screening cell-material interactions where materials are presented to cells as a 2D film or surface. However, biomaterials are frequently used to fabricate 3D scaffolds, cells exist in vivo in a 3D environment and cells cultured in a 3D environment in vitro typically behave more physiologically than those cultured on a 2D surface. Thus, we have developed a platform for fabricating tissue scaffold libraries where biomaterials can be presented to cells in a 3D format.
|
| 巻・号 |
671
|
| ページ |
161-74
|
| 公開日 |
2011-1-1
|
| DOI |
10.1007/978-1-59745-551-0_9
|
| PMID |
20967629
|
| MeSH |
Animals
Cell Adhesion
Cell Culture Techniques / instrumentation*
Cell Line
Cell Proliferation
Combinatorial Chemistry Techniques / economics
Combinatorial Chemistry Techniques / methods*
Equipment Design
Humans
Microscopy, Electron, Scanning
Polymers / chemistry*
Porosity
Tissue Scaffolds / chemistry*
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
