論文 - 詳細
| RRC ID | 6235 |
|---|---|
| 著者 | Mapp OM, Wanner SJ, Rohrschneider MR, Prince VE. |
| タイトル | Prickle1b mediates interpretation of migratory cues during zebrafish facial branchiomotor neuron migration. |
| ジャーナル | Dev Dyn |
| Abstract |
The facial branchiomotor neurons undergo a characteristic tangential migration in the vertebrate hindbrain. Several signaling mechanisms have been implicated in this process, including the non-canonical Wnt/planar cell polarity (PCP) pathway. However, the role of this signaling pathway in controlling the dynamics of these neurons is unclear. Here, we describe the cellular dynamics of the facial neurons as they migrate, focusing on the speed and direction of migration, extension of protrusions, cell shape, and orientation. Furthermore, we show that the PET/LIM domain protein Prickle1b (Pk1b) is required for several aspects of these migratory behaviors, including cell orientation. However, we find that centrosome localization is not significantly affected by disruption of Pk1b function, suggesting that polarization of the neurons is not completely lost. Together, our data suggest that Pk1b function may be required to integrate the multiple migratory cues received by the neurons into polarization instructions for proper posterior movement. |
| 巻・号 | 239(6) |
| ページ | 1596-608 |
| 公開日 | 2010-6-1 |
| DOI | 10.1002/dvdy.22283 |
| PMID | 20503357 |
| PMC | PMC3075581 |
| MeSH | Adaptor Proteins, Signal Transducing Animals Animals, Genetically Modified Carrier Proteins Cell Movement / physiology* Cell Polarity / physiology Embryo, Nonmammalian Face / innervation LIM Domain Proteins Neurogenesis Neurons / metabolism Rhombencephalon / metabolism Signal Transduction / physiology Zebrafish / metabolism* Zebrafish Proteins |
| IF | 3.275 |
| 引用数 | 37 |
| WOS 分野 | ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | rw013(Tg (zCREST1-hsp70:GFP))? |