Reference - Detail
| RRC ID | 62561 |
|---|---|
| Author | Chang HS, Endoh D, Ishida Y, Takahashi H, Ozawa S, Hayashi M, Yabuki A, Yamato O. |
| Title | Radioprotective effect of alk(en)yl thiosulfates derived from allium vegetables against DNA damage caused by X-ray irradiation in cultured cells: antiradiation potential of onions and garlic. |
| Journal | ScientificWorldJournal |
| Abstract |
To evaluate a radioprotective effect of sodium n-propyl thiosulfate (NPTS) and sodium 2-propenyl thiosulfate (2PTS) derived from onions and garlic, respectively, rat hepatoma H4IIE cells and mouse lymphoma L5178Y cells were preincubated with each of these compounds for 48 hours at 37°C before receiving 10 Gy of X-ray irradiation. Cell damage caused by the irradiation was quantified as comet tail moment, which represents the degree of DNA damage. X-ray-induced DNA damage was significantly decreased in both H4IIE and L5178Y cells by micromolar concentrations of NPTS and 2PTS compared with the control without the compounds. The protective effect was more potent with 2PTS than NPTS. Onions and garlic have antiradiation potential. |
| Volume | 2012 |
| Pages | 846750 |
| Published | 2012-1-1 |
| DOI | 10.1100/2012/846750 |
| PMID | 22919357 |
| PMC | PMC3417205 |
| MeSH | Animals Cell Line, Tumor Cells, Cultured Comet Assay Garlic* Onions* Radiation-Protective Agents / pharmacology* Rats Thiosulfates / pharmacology* X-Rays* |
| Altmetric score |
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| The most frequently cited source | |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | L5178Y(RCB0135) |