論文 - 詳細
| RRC ID | 62734 |
|---|---|
| 著者 | Okada M, Kuramoto K, Takeda H, Watarai H, Sakaki H, Seino S, Seino M, Suzuki S, Kitanaka C. |
| タイトル | The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo. |
| ジャーナル | Oncotarget |
| Abstract |
A phase 2 clinical trial investigating the efficacy and safety of AS602801, a newly developed JNK inhibitor, in the treatment of inflammatory endometriosis is complete. We are now examining whether AS602801 acts against human cancer cells in vitro and in vivo. In vitro, AS602801 exhibited cytotoxicity against both serum-cultured non-stem cancer cells and cancer stem cells derived from human pancreatic cancer, non-small cell lung cancer, ovarian cancer and glioblastoma at concentrations that did not decrease the viability of normal human fibroblasts. AS602801 also inhibited the self-renewal and tumor-initiating capacity of cancer stem cells surviving AS602801 treatment. Cancer stem cells in established xenograft tumors were reduced by systemic administration of AS602801 at a dose and schedule that did not adversely affect the health of the tumor-bearing mice. These findings suggest AS602801 is a promising anti-cancer stem cell agent, and further investigation of the utility of AS602801 in the treatment of cancer seems warranted. |
| 巻・号 | 7(19) |
| ページ | 27021-32 |
| 公開日 | 2016-5-10 |
| DOI | 10.18632/oncotarget.8395 |
| PII | 8395 |
| PMID | 27027242 |
| PMC | PMC5053629 |
| MeSH | A549 Cells Animals Benzothiazoles / pharmacology* Cell Line Cell Line, Tumor Cell Survival / drug effects Humans JNK Mitogen-Activated Protein Kinases / antagonists & inhibitors JNK Mitogen-Activated Protein Kinases / metabolism Male Mice, Inbred BALB C Mice, Nude Neoplasms / drug therapy* Neoplasms / pathology Neoplastic Stem Cells / drug effects* Neoplastic Stem Cells / pathology Pyrimidines / pharmacology* Tumor Burden / drug effects Xenograft Model Antitumor Assays / methods* |
| IF | 5.168 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) |