論文 - 詳細
| RRC ID | 62749 |
|---|---|
| 著者 | Yasuma T, Yano Y, D'Alessandro-Gabazza CN, Toda M, Gil-Bernabe P, Kobayashi T, Nishihama K, Hinneh JA, Mifuji-Moroka R, Roeen Z, Morser J, Cann I, Motoh I, Takei Y, Gabazza EC. |
| タイトル | Amelioration of Diabetes by Protein S. |
| ジャーナル | Diabetes |
| Abstract |
Protein S is an anticoagulant factor that also regulates inflammation and cell apoptosis. The effect of protein S on diabetes and its complications is unknown. This study compared the development of diabetes between wild-type and transgenic mice overexpressing human protein S and the development of diabetic glomerulosclerosis between mice treated with and without human protein S and between wild-type and protein S transgenic mice. Mice overexpressing protein S showed significant improvements in blood glucose level, glucose tolerance, insulin sensitivity, and insulin secretion compared with wild-type counterparts. Exogenous protein S improved insulin sensitivity in adipocytes, skeletal muscle, and liver cell lines in db/db mice compared with controls. Significant inhibition of apoptosis with increased expression of BIRC3 and Bcl-2 and enhanced activation of Akt/PKB was induced by protein S in islet β-cells compared with controls. Diabetic wild-type mice treated with protein S and diabetic protein S transgenic mice developed significantly less severe diabetic glomerulosclerosis than controls. Patients with type 2 diabetes had significantly lower circulating free protein S than healthy control subjects. This study shows that protein S attenuates diabetes by inhibiting apoptosis of β-cells and the development of diabetic nephropathy. |
| 巻・号 | 65(7) |
| ページ | 1940-51 |
| 公開日 | 2016-7-1 |
| DOI | 10.2337/db15-1404 |
| PII | db15-1404 |
| PMID | 27207541 |
| MeSH | Adipocytes / drug effects Adipocytes / metabolism Animals Apoptosis / drug effects Blood Glucose / metabolism Cell Line Diabetes Mellitus, Experimental / genetics* Diabetes Mellitus, Experimental / metabolism Diabetes Mellitus, Type 1 / genetics* Diabetes Mellitus, Type 1 / metabolism Diabetes Mellitus, Type 2 / genetics* Diabetes Mellitus, Type 2 / metabolism Diabetic Nephropathies / genetics* Diabetic Nephropathies / metabolism Female Glucose Tolerance Test Humans Insulin Resistance / physiology Insulin-Secreting Cells / drug effects Insulin-Secreting Cells / metabolism Liver / drug effects Liver / metabolism Male Mice Mice, Transgenic Middle Aged Muscle, Skeletal / drug effects Muscle, Skeletal / metabolism Protein S / genetics* Protein S / metabolism Protein S / pharmacology* |
| IF | 7.72 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2 |