論文 - 詳細
| RRC ID | 62765 |
|---|---|
| 著者 | Morita K, Shirabe K, Taketomi A, Soejima Y, Yoshizumi T, Uchiyama H, Ikegami T, Yamashita Y, Sugimachi K, Harimoto N, Itoh S, Ikeda T, Maehara Y. |
| タイトル | Relevance of microRNA-18a and microRNA-199a-5p to hepatocellular carcinoma recurrence after living donor liver transplantation. |
| ジャーナル | Liver Transpl |
| Abstract |
There are few reports about recurrence-related microRNAs (miRNAs) after liver transplantation (LT) for hepatocellular carcinoma (HCC). The purpose of this study was to identify novel recurrence-related miRNAs after living donor liver transplantation (LDLT) for HCC. First, we performed microarray analyses of samples from a liver with primary HCC, a liver that was noncancerous, and a liver that had recurrence-metastasis from 3 patients with posttransplant recurrence. Then we selected miRNAs with consistently altered expression in both primary HCC and recurrence as potential candidates of recurrence-related miRNAs. Expression of the miRNAs in HCC and noncancerous livers was assessed in 70 HCC patients who underwent LDLT. The target genes regulated by the recurrence-related miRNAs were identified. MicroRNA-18a (miR-18a) expression was increased, and microRNA-199a-5p (miR-199a-5p) expression was decreased in both primary HCC and recurrence. Increased miR-18a expression correlated with high levels of tumor markers, large tumor size, and a high recurrence rate. Decreased miR-199a-5p expression correlated with high levels of tumor markers, portal venous invasion, and a high recurrence rate. In HCC cells, miR-18a regulated the expression of tumor necrosis factor alpha-induced protein 3 (TNFAIP3), and miR-199a-5p regulated the expression of hypoxia-inducible factor 1 alpha (HIF1A), vascular endothelial growth factor A (VEGFA), insulin-like growth factor 1 receptor, and insulin-like growth factor 2. In conclusion, increased miR-18a levels and decreased miR-199a-5p levels are relevant to HCC recurrence after LDLT. MiR-18a and miR-199a-5p could be novel therapeutic targets of recurrent HCC after LDLT. Liver Transplantation 22 665-676 2016 AASLD. |
| 巻・号 | 22(5) |
| ページ | 665-76 |
| 公開日 | 2016-5-1 |
| DOI | 10.1002/lt.24400 |
| PMID | 26783726 |
| MeSH | Carcinoma, Hepatocellular / genetics* Cell Line, Tumor Female Gene Expression Profiling Hepatitis B / complications Hepatitis C / complications Humans Hypoxia-Inducible Factor 1, alpha Subunit / metabolism Liver Neoplasms / genetics* Liver Transplantation* Lung Neoplasms / secondary Male MicroRNAs / genetics* Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local Peritoneal Neoplasms / secondary Tumor Necrosis Factor alpha-Induced Protein 3 / metabolism Vascular Endothelial Growth Factor A / metabolism |
| IF | 4.57 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HuH-7 |