Reference - Detail
| RRC ID | 62837 |
|---|---|
| Author | Aoki S, Aboshi T, Shiono Y, Kimura KI, Murata T, Arai D, Iizuka Y, Murayama T. |
| Title | Constituents of the Fruiting Body of Poisonous Mushroom Omphalotus japonicus. |
| Journal | Chem Pharm Bull (Tokyo) |
| Abstract |
Six new sesquiterpenes, tsukiyols A-C, neoilludin C, and 4-O-methylneoilludins A and B, were isolated from the fruiting body of Omphalotus japonicus (Kawam.) Kirchm. & O. K. Mill. Additionally, six known compounds, illudin S, neoilludins A-B, 5-hydroxydichomitol, ergosterolperoxide, and 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one, were also obtained. Their chemical structures were determined with MS, IR, and NMR spectra and the absolute configurations of neoilludins A-C, 4-O-methylneoilludins A, and B were determined with electronic circular dichroism (ECD). Illudin S and 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one showed cytotoxicity against human acute promyelocytic leukemia HL60 cells. Illudin S, 4-O-methylneoilludin A, B, and tsukiyol C showed growth-restoring activity against mutant yeast via Ca2+-signal transduction. |
| Volume | 68(5) |
| Pages | 436-442 |
| Published | 2020-1-1 |
| DOI | 10.1248/cpb.c19-01009 |
| PMID | 32378541 |
| MeSH | Agaricales / chemistry* Antifungal Agents / chemistry Antifungal Agents / isolation & purification Antifungal Agents / pharmacology* Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology* Calcium Signaling / drug effects Cell Proliferation / drug effects Density Functional Theory Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Fruiting Bodies, Fungal / chemistry* HL-60 Cells Humans Microbial Sensitivity Tests Molecular Conformation Mutation Saccharomyces cerevisiae / drug effects* Saccharomyces cerevisiae / genetics Saccharomyces cerevisiae / metabolism Sesquiterpenes / chemistry Sesquiterpenes / isolation & purification Sesquiterpenes / pharmacology* Structure-Activity Relationship |
| IF | 1.416 |
| Resource | |
| Human and Animal Cells | HL60(RCB0041) |