論文 - 詳細
| RRC ID | 62948 |
|---|---|
| 著者 | Tanaka N, Okuda M, Nishigaki T, Tsuchiya N, Kobayashi Y, Uemura T, Kumo S, Sugimoto H, Miyata S, Waku T. |
| タイトル | Development of a brain-permeable peptide nanofiber that prevents aggregation of Alzheimer pathogenic proteins. |
| ジャーナル | PLoS One |
| Abstract |
Alzheimer's disease (AD) is proposed to be induced by abnormal aggregation of amyloidβ in the brain. Here, we designed a brain-permeable peptide nanofiber drug from a fragment of heat shock protein to suppress aggregation of the pathogenic proteins. To facilitate delivery of the nanofiber into the brain, a protein transduction domain from Drosophila Antennapedia was incorporated into the peptide sequence. The resulting nanofiber efficiently suppressed the cytotoxicity of amyloid βby trapping amyloid β onto its hydrophobic nanofiber surface. Moreover, the intravenously or intranasally injected nanofiber was delivered into the mouse brain, and improved the cognitive function of an Alzheimer transgenic mouse model. These results demonstrate the potential therapeutic utility of nanofibers for the treatment of AD. |
| 巻・号 | 15(7) |
| ページ | e0235979 |
| 公開日 | 2020-1-1 |
| DOI | 10.1371/journal.pone.0235979 |
| PII | PONE-D-20-06596 |
| PMID | 32706773 |
| PMC | PMC7380640 |
| MeSH | Administration, Intranasal Alzheimer Disease / etiology Alzheimer Disease / pathology Alzheimer Disease / prevention & control* Amyloid beta-Peptides / administration & dosage* Animals Brain / drug effects Brain / metabolism* Disease Models, Animal* Female Memory Disorders / etiology Memory Disorders / pathology Memory Disorders / prevention & control* Mice Mice, Transgenic Nanofibers / administration & dosage* Nanofibers / chemistry Plaque, Amyloid / etiology Plaque, Amyloid / pathology Plaque, Amyloid / prevention & control* |
| IF | 2.74 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PC-12(RCB0009) |