Reference - Detail
| RRC ID | 62959 |
|---|---|
| Author | Okabe A, Huang KK, Matsusaka K, Fukuyo M, Xing M, Ong X, Hoshii T, Usui G, Seki M, Mano Y, Rahmutulla B, Kanda T, Suzuki T, Rha SY, Ushiku T, Fukayama M, Tan P, Kaneda A. |
| Title | Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma. |
| Journal | Nat Genet |
| Abstract |
Epstein-Barr virus (EBV) is associated with several human malignancies including 8-10% of gastric cancers (GCs). Genome-wide analysis of 3D chromatin topologies across GC lines, primary tissue and normal gastric samples revealed chromatin domains specific to EBV-positive GC, exhibiting heterochromatin-to-euchromatin transitions and long-range human-viral interactions with non-integrated EBV episomes. EBV infection in vitro suffices to remodel chromatin topology and function at EBV-interacting host genomic loci, converting H3K9me3+ heterochromatin to H3K4me1+/H3K27ac+ bivalency and unleashing latent enhancers to engage and activate nearby GC-related genes (for example TGFBR2 and MZT1). Higher-order epigenotypes of EBV-positive GC thus signify a novel oncogenic paradigm whereby non-integrative viral genomes can directly alter host epigenetic landscapes ('enhancer infestation'), facilitating proto-oncogene activation and tumorigenesis. |
| Volume | 52(9) |
| Pages | 919-930 |
| Published | 2020-9-1 |
| DOI | 10.1038/s41588-020-0665-7 |
| PII | 10.1038/s41588-020-0665-7 |
| PMID | 32719515 |
| MeSH | Adenocarcinoma / genetics* Adenocarcinoma / virology* Carcinogenesis / genetics Cell Line, Tumor Chromatin / genetics* Epigenomics / methods Epstein-Barr Virus Infections / genetics* Herpesvirus 4, Human / genetics* Humans Proto-Oncogene Mas Stomach Neoplasms / genetics* Stomach Neoplasms / virology* Transcription, Genetic / genetics* |
| IF | 27.605 |
| Resource | |
| Human and Animal Cells | MKN7(RCB0999) |