論文 - 詳細
| RRC ID | 63041 |
|---|---|
| 著者 | Wada Y, Morine Y, Imura S, Ikemoto T, Saito Y, Takasu C, Yamada S, Shimada M. |
| タイトル | HIF-1α expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis. |
| ジャーナル | World J Surg Oncol |
| Abstract |
BACKGROUND:The role of hypoxia-inducible factor-1α (HIF-1α) in primary colorectal cancer (CRC) and colorectal liver metastasis (CRLM) has remained unclear. The aim of this study was to investigate HIF-1α expression and its association with prognosis in patients with CRLM with a focus on hepatic stellate cells (HSCs). METHODS:Colon cancer cells were cultured in HSC-conditioned medium (CM), and HIF-1α expression and cell migration were analyzed. Seventy-five patients with CRLM who underwent an initial curative hepatectomy were enrolled. We examined HIF-1α expressions and patient prognosis between primary CRCs and the matched liver metastatic specimens. RESULTS:Activated HSCs induced HIF-1α mRNA and protein expression in colon cancer cells (p < 0.01) and promoted cell migration (p < 0.01). The positive rates of HIF-1α expression in primary CRCs and liver metastases were 68.0 and 72.0%, respectively. There were no differences in overall (OS) and disease-free survival (DFS) of HIF-1α expression in primary CRC. However, HIF-1α expression in liver metastasis correlated to poor prognosis in both OS and DFS. Furthermore, patients with HIF-1α positive expression in liver metastasis had poor prognosis. CONCLUSION:HIF-1α expression in liver metastasis determines poor prognosis of CRLM patients. HSCs might play a key role in aggressive phenotypes of tumor cells. |
| 巻・号 | 18(1) |
| ページ | 241 |
| 公開日 | 2020-9-7 |
| DOI | 10.1186/s12957-020-02012-5 |
| PII | 10.1186/s12957-020-02012-5 |
| PMID | 32895059 |
| PMC | PMC7487629 |
| MeSH | Colonic Neoplasms* Colorectal Neoplasms* Humans Hypoxia-Inducible Factor 1, alpha Subunit Liver Neoplasms* Prognosis |
| IF | 1.963 |
| リソース情報 | |
| ヒト・動物細胞 | HCT116(RCB2979) |