RRC ID 6313
Author Anyanful A, Easley KA, Benian GM, Kalman D.
Title Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity.
Journal Cell Host Microbe
Abstract Caenorhabditis elegans exhibits avoidance behavior when presented with diverse bacterial pathogens. We hypothesized that exposure to pathogens might not only cause worms to move away but also simultaneously activate pathways that promote resistance to the pathogen. We show that brief exposure to virulent or avirulent strains of the bacterial pathogen enteropathogenic E. coli (EPEC) "immunizes"C. elegans to survive a subsequent exposure that would otherwise prove lethal, a phenomenon we refer to as "conditioning." Conditioning requires dopaminergic neurons; the p38 MAP kinase pathway, which regulates innate immunity; and the insulin/IGFR pathway, which regulates lifespan. Our findings suggest that the molecular pathways that control innate immunity and lifespan may be regulated or "conditioned" by exposure to pathogens to allow survival in noxious environments.
Volume 5(5)
Pages 450-62
Published 2009-5-8
DOI 10.1016/j.chom.2009.04.012
PII S1931-3128(09)00140-1
PMID 19454349
PMC PMC2992947
MeSH Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / immunology Caenorhabditis elegans / microbiology* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / immunology Disease Models, Animal* Enteropathogenic Escherichia coli / pathogenicity* Enteropathogenic Escherichia coli / physiology Host-Pathogen Interactions Humans Immunity, Innate* Longevity* Signal Transduction Virulence p38 Mitogen-Activated Protein Kinases / genetics p38 Mitogen-Activated Protein Kinases / immunology
IF 17.872
Times Cited 36
C.elegans tm2309 tm1325