論文 - 詳細
| RRC ID | 63163 |
|---|---|
| 著者 | Matsumura E, Kosuge N, Nakanishi S, Suda T, Sugawa A, Fujimura T, Miyagi R, Yoshimi N, Saito S. |
| タイトル | Urine Lactoferrin as a Potential Biomarker Reflecting the Degree of Malignancy in Urothelial Carcinoma of the Bladder. |
| ジャーナル | Tohoku J Exp Med |
| Abstract |
Urothelial carcinoma of the bladder (UCB) is potentially life-threatening; therefore, we aimed to discover a novel urine biomarker for diagnosis and prognostication of UCB. This is a retrospective case-control study. Exploration of a new biomarker using urine from 20 UCB patients in the present study revealed that urinary level of lactoferrin (LF), a multifunctional glycoprotein released from neutrophils, was higher in 11 of 15 with invasive/high-grade UCB than 5 with non-invasive one, and 2 healthy adults. We therefore focused on LF and assessed the value of urine LF normalized by urine creatinine concentration (LF/Cr) using an enzyme-linked immunosorbent assay. Diagnostic performance of urine LF/Cr was examined using urine from 92 patients with primary (newly diagnosed) untreated UCB and 166 controls without UCB, including 62 patients with pyuria, and 104 subjects without pyuria consisting of 84 patients and 20 healthy adults. However, the diagnostic accuracies were accompanied by the risk of bias. In 92 primary UCB patients, both pyuria and tumor-infiltrating neutrophils (TINs) were independent predictors for urine LF/Cr. In contrast, TINs or urine LF/Cr were independent predictors for invasive histology, whereas pyuria was not. In terms of prognostication, urine LF/Cr and nodal metastasis were independent predictors of disease-specific survival in 22 patients with muscle-invasive bladder cancer, characterized by a high mortality rate, in the Cox proportional hazards model. In conclusion, urine LF/Cr linked to TINs was a predictor of both invasive histology and prognosis in UCB. Urine LF/Cr is a potential biomarker reflecting the degree of malignancy in UCB. |
| 巻・号 | 252(3) |
| ページ | 225-244 |
| 公開日 | 2020-11-1 |
| DOI | 10.1620/tjem.252.225 |
| PMID | 33162487 |
| MeSH | Adolescent Adult Aged Aged, 80 and over Biomarkers / urine* Carcinoma / urine* Case-Control Studies Cell Proliferation Child Enzyme-Linked Immunosorbent Assay Female Humans Lactoferrin / urine* Male Middle Aged Neoplasm Metastasis Neutrophils / metabolism Prognosis Reference Standards Retrospective Studies Urinary Bladder / pathology Urinary Bladder Neoplasms / urine* Urothelium / pathology* Young Adult |
| IF | 1.441 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | T24(RCB2536) 5637(RCB1191) |