RRC ID 63193
著者 Takheaw N, Sittithumcharee G, Kariya R, Kasinrerk W, Okada S.
タイトル Anti-human CD99 antibody exerts potent antitumor effects in mantle cell lymphoma.
ジャーナル Cancer Immunol Immunother
Abstract CD99 is a surface molecule expressed on various cell types including cancer cells. Expression of CD99 on multiple myeloma is associated with CCND1-IGH fusion/t(11;14). This translocation has been reported to be a genetic hallmark of mantle cell lymphoma (MCL). MCL is characterized by overexpression of cyclin D1 and high tumor proliferation. In this study, high expression of CD99 on MCL cell lines was confirmed. Our generated anti-CD99 monoclonal antibody (mAb), termed MT99/3, exerted potent antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) activities against mantle B-cell lymphoma without direct cytotoxic effects. The anti-tumor activities of mAb MT99/3 were more effective in MCL than in other B-cell lymphomas. Moreover, in a mouse xenograft model using Z138 MCL cell line, treatment of mAb MT99/3 reduced tumor development and growth. Our study indicated that mAb MT99/3 is a promising immunotherapeutic candidate for mantle cell lymphoma therapy.
巻・号 70(6)
ページ 1557-1567
公開日 2021-6-1
DOI 10.1007/s00262-020-02789-0
PII 10.1007/s00262-020-02789-0
PMID 33215253
MeSH 12E7 Antigen / antagonists & inhibitors 12E7 Antigen / immunology 12E7 Antigen / metabolism* Animals Antibodies, Monoclonal / pharmacology* Antibody-Dependent Cell Cytotoxicity* Antineoplastic Agents / pharmacology* Apoptosis Cell Proliferation Complement Activation* Female Humans Lymphoma, Mantle-Cell / immunology Lymphoma, Mantle-Cell / pathology Lymphoma, Mantle-Cell / therapy* Mice Mice, Inbred BALB C Mice, Nude Tumor Cells, Cultured Xenograft Model Antitumor Assays
IF 5.442
リソース情報
ヒト・動物細胞 Jurkat(RCB3052)