RRC ID 63358
Author Gallucci AF, Patterson KC, Weit AR, Van Der Pol WJ, Dubois LG, Percy AK, Morrow CD, Campbell SL, Olsen ML.
Title Microbial community changes in a female rat model of Rett syndrome.
Journal Prog Neuropsychopharmacol Biol Psychiatry
Abstract Rett syndrome (RTT) is an X-linked neurodevelopmental disorder that is predominantly caused by alterations of the methyl-CpG-binding protein 2 (MECP2) gene. Disease severity and the presence of comorbidities such as gastrointestinal distress vary widely across affected individuals. The gut microbiome has been implicated in neurodevelopmental disorders such as Autism Spectrum Disorder (ASD) as a regulator of disease severity and gastrointestinal comorbidities. Although the gut microbiome has been previously characterized in humans with RTT compared to healthy controls, the impact of MECP2 mutation on the composition of the gut microbiome in animal models where the host and diet can be experimentally controlled remains to be elucidated. By evaluating the microbial community across postnatal development as behavioral symptoms appear and progress, we have identified microbial taxa that are differentially abundant across developmental timepoints in a zinc-finger nuclease rat model of RTT compared to WT. We have additionally identified p105 as a key translational timepoint. Lastly, we have demonstrated that fecal SCFA levels are not altered in RTT rats compared to WT rats across development. Overall, these results represent an important step in translational RTT research.
Pages 110259
Published 2021-2-3
DOI 10.1016/j.pnpbp.2021.110259
PII S0278-5846(21)00018-X
PMID 33548354
IF 4.315
Rats W-Tg(S100b-EGFP)Scell (StrainID=673)