論文 - 詳細
| RRC ID | 63377 |
|---|---|
| 著者 | Murakoshi M, Gohda T, Adachi E, Ichikawa S, Hagiwara S, Suzuki Y. |
| タイトル | Differential organ-specific inflammatory response to progranulin in high-fat diet-fed mice. |
| ジャーナル | Sci Rep |
| Abstract |
Progranulin (PGRN) has been reported to bind tumor necrosis factor (TNF) receptor and to inhibit TNFα signaling. We evaluated the effect of augmentation of TNFα signaling by PGRN deficiency on the progression of kidney injury. Eight-week-old PGRN knockout (KO) and wild-type (WT) mice were fed a standard diet or high-fat diet (HFD) for 12 weeks. Albuminuria, markers of tubular damage, and renal mRNA levels of inflammatory cytokines were higher in HFD-fed KO (KO-HFD) mice than in HFD-fed WT (WT-HFD) mice. Body weight, vacuolization in proximal tubules, and systemic and adipose tissue inflammatory markers were lower in the KO-HFD mice than in the WT-HFD mice. The renal megalin expression was lower in the KO mice than in the WT mice regardless of the diet type. The megalin expression was also reduced in mouse proximal tubule epithelial cells stimulated with TNFα and in those with PGRN knockdown by small interfering RNA in vitro. PGRN deficiency was associated with both exacerbated renal inflammation and decreased systemic inflammation, including that in the adipose tissue of mice with HFD-induced obesity. Improved tubular vacuolization in the KO-HFD mice might partially be explained by the decreased expression of megalin in proximal tubules. |
| 巻・号 | 11(1) |
| ページ | 1194 |
| 公開日 | 2021-1-13 |
| DOI | 10.1038/s41598-020-80940-8 |
| PII | 10.1038/s41598-020-80940-8 |
| PMID | 33441916 |
| PMC | PMC7806827 |
| MeSH | Adipose Tissue / metabolism Animals Body Weight / physiology Cells, Cultured Diet, High-Fat / adverse effects Inflammation / metabolism* Insulin Resistance / physiology Kidney Tubules, Proximal / metabolism Low Density Lipoprotein Receptor-Related Protein-2 / metabolism Mice Mice, Inbred C57BL Mice, Knockout Obesity / metabolism Progranulins / metabolism* Signal Transduction / physiology Tumor Necrosis Factor-alpha / metabolism |
| IF | 3.998 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC02370 |